The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma
The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma
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DOI：
10.7717/peerj.8454
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发表时间：
2020-01
期刊：
影响因子：
2.7
通讯作者：
Hua Yu;Han Wang;W. Dong;Zhenying Cao;Rongjia Li;Chao Yang;W. Cong;H. Dong;Guang-Zhi Jin
中科院分区：
文献类型：
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作者：
Hua Yu;Han Wang;W. Dong;Zhenying Cao;Rongjia Li;Chao Yang;W. Cong;H. Dong;Guang-Zhi Jin
背景泛素结合酶E2 T（UBE 2 T）在几种类型的恶性肿瘤中过表达。然而，其在肝内胆管细胞癌（ICC）和其他胆管疾病的诊断意义或ICC的预后价值知之甚少。方法采用免疫组织化学方法检测UBE 2 T在肝内胆管（IHBD，N = 13）、胆管上皮内瘤变（BilIN; BilIN-1/2，N = 23; BilIN-3，N = 11）和ICC（N = 401）中的表达。并评估其鉴别诊断及预后价值。结果UBE 2 T阳性细胞在ICC组织中的表达明显高于IHBD、BilIN-1/2和BilIN-3等非癌组织。Kaplan-Meier分析显示，UBE 2 T过表达与较短的复发时间（TTR）和总生存期（OS）相关。高UBE 2 T组和低UBE 2 T组的5年TTR率分别为100%和86.2%。相应的OS率分别为1.9%和22.2%。UBE 2 T高表达是TTR（危险比：1.345; 95%可信区间：1.047，1.728）和OS（危险比：1.420; 95%可信区间：1.098，1.837）的独立危险因素。结论UBE 2 T可辅助鉴别胆管良性病变和ICC，UBE 2 T高表达提示ICC预后不良。
Background Ubiquitin-conjugating enzyme E2T (UBE2T) is overexpressed in several types of malignancies. However, little is known about its diagnostic significance in intrahepatic cholangiocarcinoma (ICC) and other bile duct diseases or its prognostic value in ICC. Methods The expression levels of UBE2T in the intrahepatic bile duct (IHBD, N = 13), biliary intraepithelial neoplasia (BilIN; BilIN-1/2, N = 23; BilIN-3, N = 11), and ICC (N = 401) were examined by immunohistochemistry. The differential diagnostic and prognostic values were also assessed. Results The number of UBE2T-positive cells was significantly higher in ICC tissues than in nonmalignant tissues, including the IHBD, BilIN-1/2, and BilIN-3 tissues. Kaplan–Meier analysis showed that overexpression of UBE2T was correlated with a shorter time to recurrence (TTR) and overall survival (OS). The 5-year TTR rates in the high UBE2T and low UBE2T groups were 100% and 86.2%, respectively. The corresponding OS rates were 1.9% and 22.2%, respectively. High expression of UBE2T was an independent risk factor for both TTR (hazard ratio: 1.345; 95% confidence interval: 1.047,1.728) and OS (hazard ratio: 1.420; 95% confidence interval: 1.098,1.837). Conclusions UBE2T can assist in differentiating benign bile duct diseases from ICC, and high expression of UBE2T suggests a poor prognosis for ICC.