Evolution of nitric oxide regulation of gut function
Evolution of nitric oxide regulation of gut function
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一氧化氮调节肠道功能的演变
DOI：
10.1073/pnas.1816973116
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yaguchi Shunsuke
中科院分区：
文献类型：
--
作者：
Yaguchi Junko;Yaguchi Shunsuke
虽然形态是多样的，在双侧的共同模式是通过肠道的食物由神经和内胚层衍生的神经元样细胞控制。在脊椎动物中，来自肠神经的一氧化氮（NO）控制幽门括约肌的松弛。在这里，我们表明，在海胆幼虫，有内胚层来源的神经元型一氧化氮合酶（nNOS）阳性细胞表达泛神经标记物，突触结合蛋白-B（SynB），在括约肌和NO调节幽门括约肌的松弛。我们的研究结果表明，NO依赖幽门调节是一个共享的功能内的后口，我们推测，这是一个特征的干后口。
Although morphologies are diverse, the common pattern in bilaterians is for passage of food in the gut to be controlled by nerves and endodermally derived neuron-like cells. In vertebrates, nitric oxide (NO) derived from enteric nerves controls relaxation of the pyloric sphincter. Here, we show that in the larvae of sea urchins, there are endoderm-derived neuronal nitric oxide synthase (nNOS)-positive cells expressing pan-neural marker, Synaptotagmin-B (SynB), in sphincters and that NO regulates the relaxation of the pyloric sphincter. Our results indicate that NO-dependent pylorus regulation is a shared feature within the deuterostomes, and we speculate that it was a characteristic of stem deuterostomes.