Cruising the cellular highways: How human papillomavirus travels from the surface to the nucleus.
Cruising the cellular highways: How human papillomavirus travels from the surface to the nucleus.
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DOI：
10.1016/j.virusres.2016.10.015
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发表时间：
2017-03-02
期刊：
影响因子：
5
通讯作者：
Sapp M
中科院分区：
文献类型：
--
作者：
DiGiuseppe S;Bienkowska-Haba M;Guion LG;Sapp M
无包膜人乳头瘤病毒 (HPV) 专门针对皮肤和粘膜的上皮细胞。成功的感染需要在分层组织中出现病变才能进入基底细胞。在此，我们讨论了我们在理解 HPV 颗粒的结合、内化、脱壳和细胞内运输方面的最新进展。我们的重点是 HPV 16 型，这是与各种肛门生殖器癌和口咽癌相关的最常见的 HPV 类型。 HPV 进入的研究揭示了感染过程中利用的许多新的细胞途径。这些包括但不限于以下内容：以前未表征的内吞作用、衣壳蛋白的膜穿透、使用逆转录体复合物运输至跨高尔基体网络、核膜破裂和有丝分裂期间微管介导的运输进入核的要求、含有HPV基因组的膜结合核内囊泡的存在以及PML的要求 用于有效转录传入病毒基因组的蛋白质。对这些途径的持续研究可能会揭示基本生物细胞过程中的新作用。
The non-enveloped human papillomaviruses (HPVs) specifically target epithelial cells of the skin and mucosa. Successful infection requires a lesion in the stratified tissue for access to the basal cells. Herein, we discuss our recent progress in understanding binding, internalization, uncoating, and intracellular trafficking of HPV particles. Our focus will be on HPV type 16, which is the most common HPV type associated with various anogenital and oropharyngeal carcinomas. The study of HPV entry has revealed a number of novel cellular pathways utilized during infection. These include but are not restricted to the following: a previously uncharacterized form of endocytosis, membrane penetration by a capsid protein, the use of retromer complexes for trafficking to the trans-Golgi network, the requirement for nuclear envelope breakdown and microtubule-mediated transport during mitosis for nuclear entry, the existence of membrane-bound intranuclear vesicles harboring HPV genome, and the requirement of PML protein for efficient transcription of incoming viral genome. The continued study of these pathways may reveal new roles in basic biological cellular processes.