Regional differences in awareness and attitudes regarding genetic testing for disease risk and ancestry
Regional differences in awareness and attitudes regarding genetic testing for disease risk and ancestry
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DOI：
10.1007/s00439-010-0845-0
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发表时间：
2010-09-01
期刊：
影响因子：
5.3
通讯作者：
Royal, Charmaine D.
中科院分区：
文献类型：
--
作者：
Jonassaint, Charles R.;Santos, Eunice R.;Royal, Charmaine D.
关于公众对基因检测的认识和态度以及影响他们观点的因素知之甚少。现有的文献主要集中在种族和社会经济差异;然而，在这里，我们关注的是美国地理区域对基因检测的认识和态度如何不同。我们比较了美国四个主要城市（俄克拉荷马州诺曼、俄亥俄州辛辛那提、纽约州哈莱姆和华盛顿特区华盛顿）452名成年人（41%黑人和67%女性）在参与遗传祖先检测之前对疾病风险和祖先遗传检测的认识和态度。OK参与者报告了更多关于他们个人祖先的细节（p = 0.02），并且比所有其他网站更重视祖先测试（p < 0.01）。纽约参与者比其他地点更有可能寻求疾病基因检测（p = 0.01），并看到更多关于一个人的祖先的好处（p = 0.02），而DC参与者报告阅读和听到更多关于非洲血统的基因检测比所有其他地点（p < 0.01）。性别、年龄、教育、自我报告的种族、宗教或既往基因检测/咨询经验不能更好地解释这些部位差异。认识和态度方面的区域差异超越了传统的人口预测因素，如种族、年龄和教育。当地的社会文化因素，而不是种族和社会经济地位，可能会影响公众的认识和信仰体系，特别是在遗传学方面。
Little is known about the lay public's awareness and attitudes concerning genetic testing and what factors influence their perspectives. The existing literature focuses mainly on ethnic and socioeconomic differences; however, here we focus on how awareness and attitudes regarding genetic testing differ by geographical regions in the US. We compared awareness and attitudes concerning genetic testing for disease risk and ancestry among 452 adults (41% Black and 67% female) in four major US cities, Norman, OK; Cincinnati, OH; Harlem, NY; and Washington, DC; prior to their participation in genetic ancestry testing. The OK participants reported more detail about their personal ancestries (p = 0.02) and valued ancestry testing over disease testing more than all other sites (p < 0.01). The NY participants were more likely than other sites to seek genetic testing for disease (p = 0.01) and to see benefit in finding out more about one's ancestry (p = 0.02), while the DC participants reported reading and hearing more about genetic testing for African ancestry than all other sites (p < 0.01). These site differences were not better accounted for by sex, age, education, self-reported ethnicity, religion, or previous experience with genetic testing/counseling. Regional differences in awareness and attitudes transcend traditional demographic predictors, such as ethnicity, age and education. Local sociocultural factors, more than ethnicity and socioeconomic status, may influence the public's awareness and belief systems, particularly with respect to genetics.