Working in memory deficits and levels of N-acetylaspartate patients with schizophreniform disorder
Working in memory deficits and levels of N-acetylaspartate patients with schizophreniform disorder
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DOI：
10.1176/appi.ajp.160.3.483
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发表时间：
2003-03-01
影响因子：
17.7
通讯作者：
Nardini, M
中科院分区：
文献类型：
--
作者：
Bertolino, A;Sciota, D;Nardini, M
目的：作者使用质子磁共振光谱成像（H-1-MRSI）评估精神分裂症样障碍患者海马区和背外侧前额叶皮层中N-乙酰天冬氨酸（神经元完整性的标志物）的潜在减少。此外，他们评估了N-乙酰天冬氨酸水平和工作记忆deficits.Method：24例DSM-IV精神分裂症样障碍患者和24名健康受试者进行了研究。结果：精神分裂症样障碍患者海马区和背外侧前额叶皮层的N-乙酰天冬氨酸比率选择性降低，背外侧前额叶皮层的N-乙酰天冬氨酸比率与2-back工作记忆条件下的成绩呈正相关。与精神分裂症研究中报道的结果相似，在精神分裂症样障碍患者中观察到海马区和背外侧前额叶皮层的N-乙酰天冬氨酸减少。此外，研究结果支持了其他证据，即背外侧前额叶皮层的神经元病理学占疾病开始时已经存在的工作记忆缺陷的比例。
Objective: The authors used proton magnetic resonance spectroscopic imaging (H-1-MRSI) to assess potential reductions of N-acetylaspartate (a marker of neuronal integrity) in the hippocampal area and dorsolateral prefrontal cortex of patients with schizophreniform disorder. In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits.Method: Twenty-four patients with DSM-IV schizophreniform disorder and 24 healthy subjects were studied. Subjects underwent H-1-MRSI and were given the N-back working memory test.Results: The schizophreniform disorder patients had selective reductions of N-acetylaspartate ratios in the hippocampal area and the dorsolateral prefrontal cortex, and a positive correlation was seen between N-acetylaspartate ratios in the dorsolateral prefrontal cortex and performance during the 2-back working memory condition.Conclusions: Similar to findings reported in schizophrenia studies, N-acetylaspartate reductions in the hippocampal area and the dorsolateral prefrontal cortex were seen in patients with schizophreniform disorder. Moreover, the results support other evidence that neuronal pathology in the dorsolateral prefrontal cortex accounts for a proportion of working memory deficits already present at illness outset.