Aging of the optic nerve.
Aging of the optic nerve.
复制标题
视神经老化。
DOI：
10.1001/archopht.1980.01020040905024
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发表时间：
1980
影响因子：
--
通讯作者：
S. Drance
中科院分区：
文献类型：
--
作者：
C. L. Dolman;A. Mccormick;S. Drance
对300条视神经进行了组织学研究，年龄从出生到96岁。视神经很小，在出生时几乎没有髓鞘。它迅速生长并形成髓质。随着年龄的增长，软脑膜和纤维间隔变得更宽，并占据神经横截面积越来越大的比例。轴突逐渐减少，这可能主要反映了神经节细胞的损失，并将在很大程度上导致老年人视力下降。其他与年龄相关的退行性变化是淀粉体和星形胶质细胞胞质中的脂褐素。在老年人群中，瘢痕、轴突肿胀和施纳贝尔海绵样变性变得常见，表明血管损伤的发生率很高。
Histologic studies were carried out on 300 optic nerves covering ages from birth to 96 years. The optic nerve is small and nearly unmyelinated at birth. It rapidly grows and becomes medullated. With advancing years, the leptomeninges and fibrous septa become broader and occupy an increasingly larger proportion of the cross-sectional area of the nerve. The axons progressively diminish, and this probably reflects primarily a loss of ganglion cells and would contribute considerably to reduced visual acuity in the older population. Other age-associated degenerative changes are corpora amylacea and lipofuscin in astrocytic cytoplasm. In the older population, scars, swollen axons, and Schnabel's cavernous degeneration become common, indicating a high incidence of vascular impairment.