Developmental course of autistic social impairment in males.
Developmental course of autistic social impairment in males.
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DOI：
10.1017/s095457940900008x
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发表时间：
2009
影响因子：
3.3
通讯作者：
Todd, Richard D.
中科院分区：
文献类型：
--
作者：
Constantino, John N.;Abbacchi, Anna M.;Lavesser, Patricia D.;Reed, Hannah;Givens, Leah;Chiang, Lily;Gray, Teddi;Gross, Maggie;Zhang, Yi;Todd, Richard D.
最近的研究表明，自闭症社交障碍（ASI）在自然界中持续分布，并且微妙的类似自闭症的社交障碍在患有广泛性发育障碍（PDD）儿童的家庭成员中聚集。本研究调查了患有和不患有 PDD 的 3 至 18 岁男孩的定量特征 ASI 的纵向过程。我们使用社会反应量表 (SRS) 在相隔 1-5 年的两个时间点对 95 名流行病学确定的男性对男性双胞胎和 95 名受影响儿童的临床样本进行了评估。纵向病程被检查为年龄、PDD 家族负担和基线自闭症严重程度的函数。随着时间的推移，SRS 分数的个体间差异高度保留，整个样本的重测相关性为 0.90。在研究期间，SRS 分数总体上表现出适度的改善；个体轨迹随着基线严重程度的变化而变化，并且具有高度家族性。 ASI 的定量测量反映了可遗传的性状特征。这种测量可以作为遗传和神经生物学研究中表型严重程度的可靠指标，并且对于确定干预措施的增量反应具有潜在的实用性。
Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature, and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively-characterized ASI in 3 to 18 year old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male-male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1–5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Inter-individual variation in SRS scores was highly preserved over time, with test-retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable trait-like characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention.