Mammographic densities and risk of breast cancer among subjects with a family history of this disease
Mammographic densities and risk of breast cancer among subjects with a family history of this disease
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DOI：
10.1093/jnci/91.16.1404
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发表时间：
1999-08-18
期刊：
影响因子：
--
通讯作者：
Tritchler, DL
中科院分区：
文献类型：
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作者：
Boyd, NF;Lockwood, GA;Tritchler, DL
背景资料：已知乳腺癌家族史会增加疾病的风险，但可能存在其他改变这种风险的遗传和环境因素。其中一个因素是乳房X线摄影密度，我们已经寻找证据表明，它与有乳腺癌家族史的女性患乳腺癌的风险增加有关。研究方法：我们使用了一项基于加拿大国家乳腺筛查研究（NBSS）的巢式病例对照研究的数据，从354例在进入NBSS后至少12个月检测到乳腺癌的病例患者和354例匹配的对照受试者中，我们分析了根据三个非相互排斥的标准之一确定为有乳腺癌家族史的受试者。我们通过放射学和计算机辅助测量方法比较了病例组和对照组的乳腺摄影密度。结果如下：在调整乳腺癌的其他危险因素后，乳腺密度最广泛和最不广泛类别之间的相对危险度（RR）如下：对于至少一个一级亲属患乳腺癌，RR = 11.14（95%置信区间[CI] = 1.54-80.39）;对于至少两名受影响的一级或二级亲属，RR = 2.57（95% CI = 0.23-28.22）;对于至少一个患有乳腺癌的一级或二级亲属，RR = 5.43（95% CI = 1.85-15.88），结论：这些结果表明，乳房X线摄影密度可能与有乳腺癌家族史的女性患乳腺癌的风险密切相关。由于乳房X线摄影密度可以通过饮食和激素干预来改变，因此研究结果表明了预防有乳腺癌家族史的女性患乳腺癌的潜在方法。
Background: A family history of breast cancer is known to increase risk of the disease, but other genetic and environmental factors that modify this risk are likely to exist. One of these factors is mammographic density, and we have sought evidence that it is associated with increased risk of breast cancer among women with a family history of breast cancer. Methods: We used data from a nested case-control study based on the Canadian National Breast Screening Study (NBSS), From 354 case patients with incident breast cancer detected at least 12 months after entry into the NBSS and 354 matched control subjects, we analyzed subjects who were identified as having a family history of breast cancer according to one of three, nonmutually exclusive, criteria. We compared the mammographic densities of case patients and control subjects by radiologic and computer-assisted methods of measurement. Results: After adjustment for other risk factors for breast cancer, the relative risks (RRs) between the most and least extensive categories of breast density were as follows: For at least one first-degree relative with breast cancer, RR = 11.14 (95% confidence interval [CI] = 1.54-80.39); for at least two affected first- or second-degree relatives, RR = 2.57 (95% CI = 0.23-28.22); for at least one first- or second-degree relative with breast cancer, RR = 5.43 (95% CI = 1.85-15.88), Conclusions: These results suggest that mammographic density may be strongly associated with risk of breast cancer among women with a family history of the disease. Because mammographic densities can be modified by dietary and hormonal interventions, the results suggest potential approaches to the prevention of breast cancer in women with a family history of breast cancer.