Neuromagnetic signatures of syllable processing in fetuses and infants provide no evidence for habituation
Neuromagnetic signatures of syllable processing in fetuses and infants provide no evidence for habituation
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DOI：
10.1016/j.earlhumdev.2016.04.002
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发表时间：
2016-09-01
影响因子：
2.5
通讯作者：
Muenssinger, Jana
中科院分区：
文献类型：
--
作者：
Hartkopf, Julia;Schleger, Franziska;Muenssinger, Jana
背景：习惯化是学习的一种基本形式，其特征是重复刺激后神经元反应幅度的降低。最近的研究表明，不同频率的纯音习惯化发生在胎儿和婴儿。目的：不同音节的胎儿和婴儿的神经加工进行了研究。研究设计：听觉习惯化范式，包括两个不同的音节序列，每个主题。每个序列由八个音节组成（序列/ba/：5 x /ba/，1 x /bi/（dishabituator），2 x/ba/;序列/bi/：5 x /bi/，1 x /ba/（dishabituator），2 x /bi/）。每名受试者接受140个序列的刺激。应用胎儿脑磁图（fMEG）记录了30例胎龄28-39周胎儿和28例0-3月龄婴儿的脑磁信号。42的60个胎儿的录音和29的58个婴儿录音被列入最终analysis.Outcome措施：AERs被记录和振幅归一化的振幅的第一stimulation.Results：在胎儿和婴儿，AERs的振幅被发现不减少与重复刺激。然而，在婴儿中，音节6（disabituator）的振幅显着增加相比，音节5（p = 0.026）。结论：胎儿和婴儿表现出AER音节。与胎儿不同，婴儿对音节表现出辨别性的神经反应。在胎仔或婴儿中均未观察到习惯化。这些发现可能是重要的早期认知能力的调查，并可能有助于更好地了解儿童发展过程中的语言习得。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Background: Habituation, as a basic form of learning, is characterized by decreasing amplitudes of neuronal reaction following repeated stimuli. Recent studies indicate that habituation to pure tones of different frequencies occurs in fetuses and infants.Aims: Neural processing of different syllables in fetuses and infants was investigated.Study design: An auditory habituation paradigm including two different sequences of syllables was presented to each subject. Each sequence consisted of eight syllables (sequence/ba/: 5 x /ba/, 1 x /bi/(dishabituator), 2 x/ba/; sequence/bi/: 5 x /bi/, 1 x /ba/(dishabituator), 2 x /bi/). Each subject was stimulated with 140 sequences. Neuromagnetic signatures of auditory-evoked responses (AER) were recorded by fetal magnetoencephalography (fMEG).Subjects: Magnetic brain signals of N = 30 fetuses (age: 28-39 weeks of gestation) and N = 28 infants (age: 0-3 months) were recorded. Forty-two of the 60 fetal recordings and 29 of the 58 infant recordings were included in the final analysis.Outcome measures: AERs were recorded and amplitudes were normalized to the amplitude of the first stimulus.Results: In both fetuses and infants, the amplitudes of AERs were found not to decrease with repeated stimulation. In infants, however, amplitude of syllable 6 (dishabituator) was significantly increased compared to syllable 5 (p = 0.026).Conclusions: Fetuses and infants showed AERs to syllables. Unlike fetuses, infants showed a discriminative neural response to syllables. Habituation was not observed in either fetuses or infants. These findings could be important for the investigation of early cognitive competencies and may help to gain a better understanding of language acquisition during child development. (C) 2016 Elsevier Ireland Ltd. All rights reserved.