No effect of recombination on the efficacy of natural selection in primates
No effect of recombination on the efficacy of natural selection in primates
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DOI：
10.1101/gr.071548.107
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发表时间：
2008-04-01
期刊：
影响因子：
7
通讯作者：
Coop, Graham
中科院分区：
文献类型：
--
作者：
Bullaughey, Kevin;Przeworski, Molly;Coop, Graham
群体遗传理论表明，自然选择在低重组区域中应该不太有效，这可能导致重组环境之间的适应率存在差异。迄今为止，这一预测主要在果蝇中进行了测试，但结果有些矛盾。我们通过考虑人类、黑猩猩和恒河猴之间的蛋白质进化率（以 dN/dS 测量），研究了人类重组率与灵长类动物适应之间的关联。一旦考虑到 GC 含量，我们发现粗重组率和细重组率与蛋白质进化率之间不存在相关性。此外，重组极低区域中的基因预计会表现出选择效率最显着的降低，但它们的进化速度与其他基因并无不同。因此，没有证据表明重组环境中的选择功效存在差异。一个有趣的暗示是，重组修饰因子的间接选择可能是灵长类动物进化中的一个弱力量。
Population genetic theory suggests that natural selection should be less effective in regions of low recombination, potentially leading to differences in rates of adaptation among recombination environments. To date, this prediction has mainly been tested in Drosophila, with somewhat conflicting results. We investigated the association between human recombination rates and adaptation in primates, by considering rates of protein evolution (measured by dN/dS) between human, chimpanzee, and rhesus macaque. We found no correlation between either broad- or fine-scale rates of recombination and rates of protein evolution, once GC content is taken into account. Moreover, genes in regions of very low recombination, which are expected to show the most pronounced reduction in the efficacy of selection, do not evolve at a different rate than other genes. Thus, there is no evidence for differences in the efficacy of selection across recombinational environments. An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution.