Oxidation of phosphatidylcholine membranes by singlet oxygen generated in the gas phase.
Oxidation of phosphatidylcholine membranes by singlet oxygen generated in the gas phase.
复制标题
气相中产生的单线态氧氧化磷脂酰胆碱膜。
DOI：
10.1111/j.1751-1097.1992.tb02186.x
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发表时间：
1992
影响因子：
3.3
通讯作者：
Stevenson,RJ
中科院分区：
文献类型：
--
作者：
Eisenberg,WC;Anand,J;Wang,S;Stevenson,RJ
非均相光敏化在气相中生成单线态氧(1O2)，并被气泡注入磷脂酰胆碱(PC)脂质体悬浮液中。观察到脂质过氧化和膜溶解，并依赖于1O2浓度和脂质体的不饱和程度。基于大靶标扩散理论的分析表明，大的二油酰基PC、二甘油酰基PC和二异戊烯酰基PC脂质体的裂解分别需要大约5000、2800和1600个相互作用。
Singlet‐oxygen (1O2) was generated in the gas phase by heterogeneous photosensitization and bubbled into suspensions of phosphatidylcholine (PC) liposomes. Lipid peroxidation and membrane lysis were observed, and were dependent on the1O2concentration and the degree of unsaturation of the liposome. An analysis based on large target diffusion theory indicates that approximately 5000, 2800, and 1600 interactions were required for the lysis of large dioleoylPC, dilinoleoylPC and dilinolenoylPC liposomes, respectively.