Subjective memory complaints in elders: depression, anxiety, or cognitive decline?
Subjective memory complaints in elders: depression, anxiety, or cognitive decline?
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DOI：
10.1111/ane.12038
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发表时间：
2013-05-01
影响因子：
3.5
通讯作者：
Korczyn, A. D.
中科院分区：
文献类型：
--
作者：
Balash, Y.;Mordechovich, M.;Korczyn, A. D.
目的探讨老年人主观记忆主诉(SMC)与情感状态和认知表现的关系。材料与方法对健康体检正常的社区居住老年人进行研究。参与者完成了关于记忆困难和生活习惯的问卷调查，老年抑郁量表(GDS)和斯皮尔伯格状态-特质焦虑问卷(STAI)。根据参与者对有关他们记忆状况的问题的回答，参与者被分为抱怨者和非抱怨者，并根据他们的MMSE分数分为五组。这些数据已经与MindStreams的客观认知表现进行了比较，MindStreams是一种计算机化的神经心理学电池。对与SMC(因变量)相关的因素进行Logistic回归分析，计算优势比(OR)和95%可信区间(CI)。结果636例受试者(61%为女性)中，507例(79.7%)有SMC。SMC的存在与MMSE评分呈负相关(r=0.108；趋势P=0.007)。SMC患者的GDS和STAI得分较高(OR=1.23：CI 95%：1.11.36和OR=1.03：CI 95%：1.011.07)。SMC与MindStreams测量的客观认知表现没有相关性。结论在认知功能正常的健康老年人中，主观记忆主诉与亚综合征抑郁和焦虑有关。
Objectives To study the association of subjective memory complaints (SMC) with affective state and cognitive performance in elders. Materials and methods We studied community dwelling elderly persons with normal physical examination. Participants completed questionnaires regarding memory difficulties and lifestyle habits, the Geriatric Depression Scale (GDS) and the Spielberger State-Trait Anxiety Inventory (STAI). Depending on their answers to the question about their memory condition, participants were divided into complainers and non-complainers and to five groups according to their MMSE scores. These data have been compared to objective cognitive performance according to Mindstreams - a computerized neuropsychological battery. A logistic regression was performed to evaluate odds ratios (OR) and 95% confidence intervals (CI) for those factors, which were associated with SMC (dependent variable). Results Of 636 consecutive subjects (61% females), 507 participants (79.7%) had SMC. Presence of SMC was inversely correlated with MMSE scores, (r=0.108; P for trend=0.007). GDS and STAI scores were higher among subjects with SMC (OR=1.23: CI 95%: 1.11.36 and OR=1.03: CI 95%: 1.011.07, respectively). SMC did not correlate with objective cognitive performance measured by Mindstreams. Conclusions Subjective memory complaints are associated with sub-syndromal depression and anxiety in healthy cognitively normal elders.