Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma
Infection of less virulent Helicobacter pylori strains in asymptomatic healthy individuals in Thailand as a potential contributing factor to the Asian enigma
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DOI：
10.1016/j.micinf.2009.12.007
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发表时间：
2010-03-01
影响因子：
5.8
通讯作者：
Wangroongsarb, Piyada
中科院分区：
文献类型：
--
作者：
Hirai, Itaru;Sasaki, Tadahiro;Wangroongsarb, Piyada
在泰国，尽管幽门螺杆菌感染的患病率很高，但胃癌的发病率相当低。我们调查了H. pylori感染和cagA基因型的使用179粪便标本获得无症状的泰国个人。在这项研究中，H。pylori感染率为43.6%，cagA阳性菌株检出率为43.5%。此外，强毒力东亚型cagA的比例为7.2%。提示cagA阳性H. pylori基因型以及东亚基因型cagA阳性菌株的低流行率可能是胃癌发病率低的原因。(C)2009年Elsevier Masson SAS。All rights reserved.
In Thailand, gastric cancer incidence is considerably low despite the high prevalence of Helicobacter pylori infection. We investigated the prevalence of H. pylori infection and the genotypes of cagA by using 179 stool specimens obtained from asymptomatic Thai individuals. In this study, the prevalence of H. pylori infection was 43.6%, and the detection rate of cagA-positive strains was 43.5%. In addition, the proportion of the highly virulent East-Asian type of cagA was 7.2%. These results indicate that the low prevalence of cagA-positive H. pylori strain as well as the low prevalence of East-Asian genotype cagA-positive strains may contribute to the low gastric cancer incidence. (C) 2009 Elsevier Masson SAS. All rights reserved.