Is there a solution to publication bias? Researchers call for changes in dissemination of clinical research results
Is there a solution to publication bias? Researchers call for changes in dissemination of clinical research results
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DOI：
10.1016/j.jclinepi.2014.06.002
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发表时间：
2014-10-01
影响因子：
7.2
通讯作者：
Marusic, Ana
中科院分区：
文献类型：
--
作者：
Malicki, Mario;Marusic, Ana
目的：探讨临床试验和科克伦系统评价报告作者对防止发表偏倚的原因和方法的看法。研究设计和设置：设计了一个在线问卷，并发送给在高影响力或国家通用医学期刊上发表的研究人员，科克伦系统评价的作者，以及一般人群的研究人员。对有关发表偏倚的开放式问题进行定性分析。我们还举行了一个焦点小组，有经验的研究人员和/或科克伦reviewers.Results：出版偏见是常见的：48（36%）的受访者有自己的未发表的试验和40（30%）承认选择性的结果报告，但研究人员强烈认为，责任在于也与系统，促进和增强出版偏见的做法。对调查答复和焦点小组讨论的定性分析确定了通过增加透明度、改进试验登记、搜索引擎和数据库、加强机构审查委员会的作用、积极鼓励科学家和政策变化来减少发表偏倚的可能方法。虽然很清楚这个问题，临床研究人员故意造成选择性报告和不发表试验的问题。他们呼吁改变目前以期刊为基础的试验报告交流做法，并对减少出版偏倚的措施进行系统评价。(C)2014爱思唯尔公司All rights reserved.
Objectives: To explore opinions of authors of published reports of clinical trials and Cochrane systematic reviews on the causes and methods of preventing publication bias.Study Design and Setting: An online questionnaire was developed and sent to researchers publishing in high-impact or national general medical journals, authors of Cochrane systematic reviews, and a general population of researchers. Open-ended questions about publication bias were qualitatively analyzed. We also held a focus group with experienced researchers and/or Cochrane reviewers.Results: Publication bias was common: 48 (36%) respondents had own unpublished trials and 40 (30%) admitted selective outcome reporting; but researchers felt strongly that blame rested also with the system that promotes and augments publication bias practices. Qualitative analysis of both survey responses and focus group discussion identified possible ways of reducing publication bias through increased transparency, improvements to trial registries, search engines and databases, enhancement of the role of institutional review boards, positive encouragement of scientists, and policy changes.Conclusion: Although well aware of the problem, clinical researchers knowingly contribute to problems of selective reporting and non-publication of trials. They call for changes in current practices of journal-based communication of trial reporting and for systematic evaluation of measures to decrease publication bias. (C) 2014 Elsevier Inc. All rights reserved.