Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23.
Membrane and integrative nuclear fibroblastic growth factor receptor (FGFR) regulation of FGF-23.
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DOI：
10.1074/jbc.a114.609230
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Xiaobin Han;Zhousheng Xiao;Darryl Quarles
中科院分区：
文献类型：
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作者：
Xiaobin Han;Zhousheng Xiao;Darryl Quarles
背景：局部骨源性因子调节FGF-23的机制尚不清楚。结果如下：低分子量和高分子量FGF-2分别通过膜FGFR介导的NFAT和Ets 1的PLC和MAPK激活以及涉及cAMP/CBP/CREB信号通路的整合核FGFR 1信号通路刺激成骨细胞中FGF-23启动子活性。结论：FGF-23的转录受细胞膜FGFR和细胞核内FGFR/CBP通路的调控。意义：旁分泌/自分泌FGF控制激素FGF-23。
Background: Mechanisms whereby local bone-derived factors regulate FGF-23 are unclear. Results: Low and high molecular weight FGF-2 stimulated FGF-23 promoter activity in osteoblasts through membrane FGFRmediated PLC and MAPK activation of NFAT and Ets1 and integrative nuclear FGFR1 signaling involving cAMP/CBP/CREB signaling pathways, respectively. Conclusion: Membrane FGFR and intranucelar FGFR/CBP pathways regulate FGF-23 transcription. Significance: Paracrine/autocrine FGFs control hormonal FGF-23.