QUALITY AND BIOAVAILABILITY OF TETRACYCLINE CAPSULES IN A NIGERIAN SEMIURBAN COMMUNITY
QUALITY AND BIOAVAILABILITY OF TETRACYCLINE CAPSULES IN A NIGERIAN SEMIURBAN COMMUNITY
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DOI：
10.1016/0924-8579(94)00064-2
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发表时间：
1995-07-01
影响因子：
10.8
通讯作者：
LAMIKANRA, A
中科院分区：
文献类型：
--
作者：
OKEKE, IN;LAMIKANRA, A
从尼日利亚半城市城镇Ile-Ife的不同分配点购买了6批四环素胶囊，并进行了重量均匀度试验、微生物含量测定和降解产物色谱测定。其中4种还进行了溶出试验和生物利用度比较研究。从创新产品的当地生产商获得的一批胶囊用作参比标准品。从这项研究中，很明显，四环素胶囊可在这个地方是较差的药品质量。这导致相对可用性较差，可能对样品环境中的高水平四环素耐药性做出了一定贡献。
Six batches of tetracycline capsules were purchased from different dispensing points in Ile-Ife, a Nigerian semi-urban town and subjected to weight uniformity tests, microbiological assay and chromatographic determination of degradation products. Four of them were also subjected to dissolution tests and a comparative bioavailability study. A batch of capsules obtained from the local manufacturer of the innovators product was used as the reference standard. From this study, it is apparent that the tetracycline capsules available in this locality are of poor pharmaceutical quality. This has led to poor relative availability and may have made some contribution to the high level of tetracycline resistance in the sample environment.