FCR GAMMA-CHAIN DELETION RESULTS IN PLEIOTROPIC EFFECTOR CELL DEFECTS
FCR GAMMA-CHAIN DELETION RESULTS IN PLEIOTROPIC EFFECTOR CELL DEFECTS
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DOI：
10.1016/0092-8674(94)90115-5
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发表时间：
1994-02-11
期刊：
影响因子：
64.5
通讯作者：
RAVETCH, JV
中科院分区：
文献类型：
--
作者：
TAKAI, T;LI, M;RAVETCH, JV
免疫球蛋白Fc受体的γ亚基是IgE高亲和力受体（Fe epsilon RI）和IgG低亲和力受体（Fe gamma RIII）的重要组成部分，并与IgG高亲和力受体（Fe gamma RI）和T细胞相关受体-CD 3复合物。它是受体组装和信号转导所必需的。靶向破坏该亚基导致免疫受损小鼠。来自γ链缺陷小鼠的活化巨噬细胞出乎意料地缺乏吞噬抗体包被颗粒的能力，尽管正常结合。在这些动物中，NK细胞介导的抗体依赖性细胞毒性和肥大细胞介导的过敏反应的缺陷是明显的，确立了FcR在这些反应中不可或缺的作用。然而，γ链的丢失似乎不会干扰T细胞的发育，因为胸腺和外周T细胞群都是正常的。因此，这些小鼠代表了用于评估这些受体在体液和细胞免疫应答中的作用的重要工具。
The gamma subunit of immunoglobulin Fc receptors is an essential component of the high-affinity receptor for IgE (Fc epsilon RI) and the low-affinity receptor for IgG (Fc gamma RIII) and is associated with the high-affinity receptor for IgG (Fc gamma RI) and the T cell receptor-CD3 complex. It is required for both receptor assembly and signal transduction. Targeted disruption of this subunit results in immunocompromised mice. Activated macrophages from gamma chain-deficient mice unexpectedly lack the ability to phagocytose antibody-coated particles, despite normal binding. Defects in NK cell-mediated antibody-dependent cytotoxicity and mast cell-mediated allergic responses are evident in these animals, establishing the indispensable role of FcRs in these responses. However, loss of gamma chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal. These mice thus represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses.