Elastic properties of epithelial cells probed by atomic force microscopy
Elastic properties of epithelial cells probed by atomic force microscopy
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DOI：
10.1016/j.bbamcr.2015.07.010
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发表时间：
2015-11-01
影响因子：
5.1
通讯作者：
Janshoff, Andreas
中科院分区：
文献类型：
--
作者：
Bruckner, Bastian R.;Janshoff, Andreas
细胞力学在细胞迁移、细胞生长、胚胎发育和肿瘤发生等生物学过程中起着至关重要的作用。上皮细胞通过细胞弹性的明确变化对包括生化和物理刺激在内的环境提示做出反应。例如，细胞可以通过调整自身的弹性和形状来区分某些属性，如粘弹性或基质的地形。活细胞是一个复杂的粘弹体，它不仅呈现由附着在细胞骨架皮质上的膜组成的壳结构，而且还通过其肌动肌球蛋白网络产生收缩力量。在这里，我们回顾了单细胞在上皮细胞层对化学和物理刺激作出反应的细胞学。本文是题为：机械生物学特刊的一部分。(C)2015爱思唯尔B.V.保留所有权利。
Cellular mechanics plays a crucial role in many biological processes such as cell migration, cell growth, embryogenesis, and oncogenesis. Epithelia respond to environmental cues comprising biochemical and physical stimuli through defined changes in cell elasticity. For instance, cells can differentiate between certain properties such as viscoelasticity or topography of substrates by adapting their own elasticity and shape. A living cell is a complex viscoelastic body that not only exhibits a shell architecture composed of a membrane attached to a cytoskeleton cortex but also generates contractile forces through its actomyosin network. Here we review cellular mechanics of single cells in the context of epithelial cell layers responding to chemical and physical stimuli. This article is part of a Special Issue entitled: Mechanobiology. (C) 2015 Elsevier B.V. All rights reserved.