Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.
Racial Differences in the Tumor Immune Landscape and Survival of Women with High-Grade Serous Ovarian Carcinoma.
复制标题
DOI：
10.1158/1055-9965.epi-21-1334
复制
发表时间：
2022-05-04
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
肿瘤浸润淋巴细胞（TIL）在卵巢癌患者中具有生存益处;然而，在种族多样的队列中进行的工作很少。本研究调查了两项基于人群的研究（每个种族组n=121）中年龄和分期匹配的非西班牙裔黑人和非西班牙裔白色女性高级别浆液性卵巢癌（HGSOC）患者的肿瘤免疫状况和生存率的种族差异。我们通过多重免疫荧光检测了TIL（CD 3+）、细胞毒性T细胞（CD 3 + CD 8+）、调节性T细胞（CD 3 + FoxP 3+）、髓样细胞（CD 11b+）和中性粒细胞（CD 11b + CD 15+）。多变量考克斯比例风险回归用于估计免疫细胞丰度与总体生存率和种族生存率之间的关联。总体而言，较高水平的TLR、细胞毒性T细胞、骨髓细胞和中性粒细胞与瘤内和瘤周区域的更好生存相关，无论组织隔室（肿瘤、基质）如何。在瘤周区域和瘤内区域的基质中观察到T调节细胞的存活率提高，但与瘤内T调节细胞无关。尽管不同种族群体的免疫细胞丰度相似，但非西班牙裔白色女性与生存率的相关性与总体结果一致，但在非西班牙裔黑人女性中，大多数相关性减弱，无统计学意义。我们的研究结果增加了现有的证据表明，一个强大的免疫浸润赋予生存优势的妇女与HGSOC，然而，非西班牙裔黑人妇女可能不会经历相同的生存优势，非西班牙裔白色妇女与HGSOC。这项研究有助于我们了解HGSOC在不同人群中的免疫流行病学。
Tumor infiltrating lymphocytes (TILs) confer a survival benefit among ovarian cancer patients; however, little work has been conducted in racially diverse cohorts. The present study investigated racial differences in the tumor immune landscape and survival of age- and stage-matched Non-Hispanic Black and Non-Hispanic White women with high-grade serous ovarian carcinoma (HGSOC) enrolled in two population-based studies (n=121 in each racial group). We measured TILs (CD3+), cytotoxic T-cells (CD3+CD8+), regulatory T-cells (CD3+FoxP3+), myeloid cells (CD11b+), and neutrophils (CD11b+CD15+) via multiplex immunofluorescence. Multivariable Cox proportional hazard regression was used to estimate the association between immune cell abundance and survival overall and by race. Overall, higher levels of TILs, cytotoxic T-cells, myeloid cells, and neutrophils were associated with better survival in the intratumoral and peritumoral region, irrespective of tissue compartment (tumor, stroma). Improved survival was noted for T-regulatory cells in the peritumoral region and in the stroma of the intratumoral region, but no association for intratumoral T-regulatory cells. Despite similar abundance of immune cells across racial groups, associations with survival among Non-Hispanic White women were consistent with the overall findings, but among Non-Hispanic Black women, most associations were attenuated and not statistically significant. Our results add to the existing evidence that a robust immune infiltrate confers a survival advantage among women with HGSOC; however, Non-Hispanic Black women may not experience the same survival benefit as Non-Hispanic White women with HGSOC. This study contributes to our understanding of the immunoepidemiology of HGSOC in diverse populations.