Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families. The Collaborative Study for the Genetics of Asthma (CSGA).
Approaches and issues in defining asthma and associated phenotypes map to chromosome susceptibility areas in large Minnesota families. The Collaborative Study for the Genetics of Asthma (CSGA).
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定义哮喘和相关表型的方法和问题映射到明尼苏达大家庭的染色体易感性区域。
DOI：
10.1046/j.1365-2222.1998.0280s1051.x
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Weber,J
中科院分区：
文献类型：
--
作者：
Blumenthal,MN;Rich,SS;King,R;Weber,J
在明尼苏达州的一组家庭中，已经证明了哮喘及其相关表型与12号染色体上的易感基因的连锁。证据在受影响的同胞对中是强有力的，而在对大谱系的分析中则是弱有力的。第二组家系几乎没有提供这种联系的证据。 在不同的家庭中表现出差异。这可能是由于几个因素，包括遗传异质性和基因-基因，或基因-环境相互作用的影响，以及所使用的样本群体的统计能力。
Evidence for linkage of asthma and its associated phenotypes with susceptibility genes on chromosome 12 has been demonstrated in one group of Minnesota families. The evidence is strong in affected sib pairs and weakens in analysis of the large pedigrees. A second group of families provided little evidence for such linkage. A discrepancy has been demonstrated in different families. This may be due to several factors, including genetic heterogeneity and gene–gene, or gene–environmental interaction effects as well as the statistical power of the sample population used.