The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases
The hypothalamic-pituitary-adrenal axis in the pathogenesis of rheumatic diseases
复制标题
DOI：
10.1016/s0889-8529(01)00004-4
复制
发表时间：
2002-03-01
影响因子：
4.5
通讯作者：
Crofford, LJ
中科院分区：
文献类型：
--
作者：
Crofford, LJ
免疫系统和神经内分泌轴之间通过共享介质和受体存在双向相互作用。几种动物模型已用于描绘下丘脑-垂体-肾上腺轴在自身免疫性炎性疾病中的反调节作用。在风湿性疾病中，如类风湿性关节炎和系统性狼疮，有证据表明神经内分泌功能改变。应力轴失调也可能导致非炎性风湿性疼痛综合征的病理生物学。
There is bi-directional interaction between the immune system and neuroendocrine axes by virtue of shared mediators and receptors. Several animal models have served to delineate a counter-regulatory role for the hypothalamic-pituitary-adrenal axis in autoimmune inflammatory diseases. In rheumatic diseases, such as rheumatoid arthritis and systemic lupus, there is evidence of altered neuroendocrine function. Stress axis dysregulation also may contribute to the pathobiology of noninflammatory rheumatic pain syndromes.