Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy
Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy
复制标题
用于联合抗菌声动力和光热疗法的过氧化银纳米颗粒
DOI：
10.1002/smll.202104160
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发表时间：
2021-11-05
期刊：
影响因子：
13.3
通讯作者：
Zhu, Zhiling
中科院分区：
文献类型：
--
作者：
Bi, Xuelong;Bai, Qiang;Zhu, Zhiling
设计用于提高氧化应激的金属过氧化物纳米颗粒被认为是生物医学应用中有前途的纳米治疗剂，包括化学疗法、光动力疗法和细菌消毒。然而，它们对治疗靶点缺乏特异性，可能对健康组织造成毒副作用。在这里，银过氧化物纳米粒子（Ag2O2 NPs）能够控制活性氧（ROS）释放的合成。杀菌性Ag+离子和ROS的释放受到超声（US）和近红外（NIR）光的外部刺激的严格调节。体外和体内研究表明，Ag2O2纳米粒子具有增强的抗菌和抗菌膜能力，10 min内杀灭效率>99.9999%，显著加速多重耐药金黄色葡萄球菌感染的皮肤伤口闭合，具有良好的细胞相容性和血液相容性。这项工作不仅提供了制备银过氧化物纳米粒子的第一个范例，而且还介绍了一种高效的非侵入性和安全的治疗模式，用于对抗细菌感染性疾病。
Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards the therapeutic target can cause toxic side effects to healthy tissues. Here, silver peroxide nanoparticles (Ag2O2 NPs) capable of controlled reactive oxygen species (ROS) release are synthesized. The release of bactericidal Ag+ ions and ROS is strictly regulated by external stimuli of ultrasound (US) and near-infrared (NIR) light. In vitro and in vivo investigations show that the Ag2O2 NPs present enhanced antibacterial and antibiofilm capabilities with a killing efficiency >99.9999% in 10 min, significantly accelerate multi-drug resistant Staphylococcus aureus infected skin wound closure with excellent cytocompatibility and hemocompatibility. This work not only provides the first paradigm for fabricating silver peroxide nanoparticle but also introduces a highly efficient noninvasive and safe therapeutic modality for combating bacterial infectious diseases.