Comparison of Responses of Ion-Channel and Simplified Pacemaker Cell Models on External Stimulation
Comparison of Responses of Ion-Channel and Simplified Pacemaker Cell Models on External Stimulation
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离子通道和简化起搏细胞模型对外部刺激的反应比较
DOI：
10.1109/bibm52615.2021.9669353
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
M. Ryzhii and E. Ryzhii
中科院分区：
文献类型：
--
作者：
Nasution;Ahmad Kamal;Sony Hartono Wijaya;Pei Gao;Rumman Mahfujul Islam;Ming Huang;Naoaki Ono;Shigehiko Kanaya;and Md Altaf-Ul-Amin;松田 憲・杉森絵里子・楠見 孝;M. Ryzhii and E. Ryzhii
对于个性化医疗的各种系统（例如植入式设备）的心脏电建模和验证，计算效率高的简化模型是更可取的。重要的是，这些模型的行为应尽可能接近基于实验数据的离子通道模型。这项工作的目的是选择参考离子通道细胞模型来调整简化模型。为此，我们应用外部刺激电流对 CellML 模型存储库中提供的复杂离子通道和简化心脏起搏器模型进行了基本分叉分析，并比较了周期长度和动作电位特性的变化。观察到的分叉行为表明所考虑的模型之间存在显着差异。
For cardiac electrical modeling and validation of various systems for personalized medicine, such as implantable devices, computationally efficient simplified models are preferable. It is important that the behavior of these models should be as close as possible to ion-channel models based on experimental data. The aim of this work is the selection of reference ion-channel cell models for tuning of simplified models. For this purpose, we performed basic bifurcation analysis of complex ion-channel and simplified cardiac pacemaker models available in the CellML Model Repository applying external stimulation current, and compared the variation of cycle lengths and action potential properties. The observed bifurcation behavior demonstrated pronounced differences among the models considered.