EFFECT OF FOLIC ACID DEFICIENCY ON ABSORPTION OF CO60- LABELED VITAMIN B12 BY RATS
EFFECT OF FOLIC ACID DEFICIENCY ON ABSORPTION OF CO60- LABELED VITAMIN B12 BY RATS
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DOI：
10.1172/jci104506
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发表时间：
1962-01-01
影响因子：
15.9
通讯作者：
CHOW, BC
中科院分区：
文献类型：
--
作者：
HSU, JM;TANTENGCO, V;CHOW, BC
通过粪便排泄试验或通过器官摄取方法测量，由拮抗剂给药或通过饮食剥夺和磺胺二甲嘧啶喂养诱导的大鼠叶酸缺乏导致口服给药的Co 60标记的维生素B12的吸收增加。然而，长期缺乏这种维生素会导致血清B12水平降低。当钴60-B12被引入到叶酸缺乏或治疗的大鼠的肠循环，它被吸收到相同的程度。这些数据表明，由于叶酸缺乏，在肠道中没有吸收缺陷。
Folic acid deficiency in rats induced by the administration of antagonist or by dietary deprivation and sulfasuxidine feeding brings about an increase in absorption of orally administered Co60-labeled vitamin B12 as measured by the fecal excretion test or by organ uptake method. However, prolonged deficiency of this vitamin results in a lower B12 serum level. When Co60-B12 is introduced into the intestinal loops of folic acid-deficient or -treated rats, it was absorbed to the same extent. These data demonstrated no absorption defect in the intestine due to folic acid deficiency.