Neonatal antibiotic treatment is a risk factor for early wheezing
Neonatal antibiotic treatment is a risk factor for early wheezing
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DOI：
10.1542/peds.2007-1232
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发表时间：
2008-04-01
期刊：
影响因子：
8
通讯作者：
Wennergren, Goeran
中科院分区：
文献类型：
--
作者：
Alm, Bernt;Erdes, Laslo;Wennergren, Goeran
OBJECTIVE.婴儿期抗生素的使用和随后肠道细菌植物群的变化被认为是哮喘发生的危险因素。然而，很难排除在喘息早期给予抗生素的可能性。因此，存在反向因果关系的风险。为了最大限度地减少反向因果关系的风险，我们已经集中在新生儿病房已经管理的抗生素的影响。在2003年对瑞典西部出生的婴儿进行的一项队列研究中，我们研究了喘息的发展。随机选择婴儿的家庭，并在孩子6个月和12个月时发送问卷。6个月问卷的应答率为68.5%，12个月问卷的应答率为68.9%。12个月时，20.2%的婴儿有1次或多次喘息发作，5.3%的婴儿有3次或3次以上喘息发作。4.1%的婴儿使用了吸入性皮质类固醇。吸入性糖皮质激素治疗喘息性疾病的独立危险因素是新生儿抗生素治疗、男性、胎龄
OBJECTIVE. The use of antibiotics in infancy and subsequent changes in the intestinal bacterial flora have been discussed as risk factors for the development of asthma. However, it has been difficult to exclude the possibility that antibiotics have been given in early episodes of wheezing. As a result, there has been a risk of reverse causation. To minimize the risk of reverse causation, we have focused on the effect of antibiotics that are already administered on the neonatal ward.METHODS. In a cohort study of infants born in western Sweden in 2003, we studied the development of wheezing. The families of the infants were randomly selected and sent a questionnaire at child ages 6 and 12 months. The response rate was 68.5% to the 6-month questionnaire and 68.9% to the 12-month questionnaire.RESULTS. At 12 months, 20.2% of infants had had 1 or more episodes of wheezing, and 5.3% had had 3 or more episodes. Inhaled corticosteroids had been taken by 4.1% of the infants. Independent risk factors for wheezing disorder treated with inhaled corticosteroids were neonatal antibiotic treatment, male gender, gestational age of