Usefulness of T2 Relaxation Time for Quantitative Prediction of Meningioma Consistency
Usefulness of T2 Relaxation Time for Quantitative Prediction of Meningioma Consistency
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DOI：
10.1016/j.wneu.2021.10.135
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发表时间：
2021-12-15
影响因子：
2
通讯作者：
Mase, Mitsuhito
中科院分区：
文献类型：
--
作者：
Yamada, Hiroshi;Tanikawa, Motoki;Mase, Mitsuhito
背景：脑膜瘤一致性是影响手术难度的关键因素之一。尽管许多研究试图通过磁共振成像结果来预测脑膜瘤的一致性，但由于大多数研究都是基于定性评估，因此没有确定的方法。因此，本研究检测了T2松弛时间（T2值）的潜力，这是一个组织特异性的定量参数，用于评估脑膜瘤一致性。方法：本研究包括16例手术治疗的18例脑膜瘤患者。术前逐像素计算所有脑膜瘤的T2值，生成T2值分布图。从这些脑膜瘤中共取出27个肿瘤标本（如果是异质的，则取多个标本），术中使用图像引导确定每个肿瘤的定位。试样的稠度是用硬度计测量的，硬度计最初是用来测量弹性橡胶等材料的硬度的，随后用干湿测量法测量了它们的含水量。-结果：术中图像引导识别的匹配部位T2值与硬度计测量的稠度（r = -0.722, P < 0.01）和含水量（r = 0.621, P = 0.01）有显著相关性。结论：T2值可作为脑膜瘤一致性的可靠定量预测指标，T2值分布图可较详细地阐明肿瘤内部结构，为手术切除提供参考。
BACKGROUND: Meningioma consistency is one of the most critical factors affecting the difficulty of surgery. Although many studies have attempted to predict meningioma consistency via magnetic resonance imaging findings, no definitive method has been established, because most have been based on qualitative evaluations. Therefore, the present study examined the potential of the T2 relaxation time (T2 value), a tissue-specific quantitative parameter, for assessment of meningioma consistency. - METHODS: Eighteen surgically treated meningiomas in 16 patients were included in the present study. Preoperatively, the T2 values of all meningiomas were calculated pixel by pixel, and a T2 value distribution map was generated. A total of 27 tumor specimens (multiple specimens were procured if heterogeneous) were taken from these meningiomas, with each localization identified intraoperatively using image guidance. The consistency of the specimens was measured with a durometer, originally a device for measuring the hardness of material such as elastic rubber, and their water content was subsequently measured using wet and dry measurements. - RESULTS: A significant correlation was found between the T2 values of the matched locations identified by image guidance intraoperatively and the consistency measured using the durometer (r = -0.722; P < 0.01) and the water content (r = 0.621; P = 0.01). In addition, the water content CONCLUSIONS: The T2 values could be a reliable quantitative predictor of meningioma consistency, and the T2 value distribution map, which elucidated the internal structure of the tumor in detail, could provide helpful information for surgical resection.