TCR vaccination in aluminum adjuvant protects against autoimmune encephalomyelitis
TCR vaccination in aluminum adjuvant protects against autoimmune encephalomyelitis
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DOI：
10.1016/j.clim.2006.01.003
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发表时间：
2006-06-01
影响因子：
8.6
通讯作者：
Aroeira, Luiz Stark
中科院分区：
文献类型：
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作者：
Aroeira, Luiz Stark
实验性变应性脑炎（EAE）是一种神经炎症性自身免疫性疾病，其中具有受限的TCRV β库的myetin反应性Th 1 T细胞发挥致病作用。在这里，我表明，一个工程化的单链TCR含有显性TCRV α/V β致脑炎元件，当在铝佐剂中给药时，产生显着的抗TCR体液反应，与保护V β 8表达B10.PL，但不是在V β 8缺陷的SJL小鼠EAE的发展。sc-TCR/Al疫苗接种通过涉及抗TCR B细胞和/或抗体的机制以TCR特异性方式在预防鼠EAE方面是高度有效的。总的来说，这些数据具有重要的意义，设计预防或治疗策略结合TCR疫苗接种与使用铝佐剂在治疗多发性硬化症和其他人类自身免疫性炎症性疾病。(c)2006年爱思唯尔公司All rights reserved.
Experimental Allergic Encephatomyetitis (EAE) is a neuroinftammatory, autoimmune disorder in which myetin-reactive Th1 T cells with a restricted TCRV beta repertoire play a pathogenic role. Here, I show that an engineered single-chain TCR containing dominant TCRV alpha/V beta encephatitogenic elements, when administered in aluminum adjuvant, generates a marked anti-TCR humoral response that correlated with protection against the development of EAE in V beta 8-expressing B10.PL but not in V beta 8-deficient SJL mice. sc-TCR/Al vaccination was highly efficient in preventing murine EAE in a TCR-specific manner through a mechanism involving anti-TCR B cells and/or antibodies. Collectively, these data have important implications for designing preventive or therapeutic strategies combining TCR vaccination with the use of aluminum adjuvant in the treatment of multiple sclerosis and other human autoimmune inflammatory diseases. (c) 2006 Elsevier Inc. All rights reserved.