A pilot study of disparity vergence and near dissociated phoria in convergence insufficiency patients before vs. after vergence therapy.
A pilot study of disparity vergence and near dissociated phoria in convergence insufficiency patients before vs. after vergence therapy.
复制标题
DOI：
10.3389/fnhum.2015.00419
复制
发表时间：
2015
影响因子：
2.9
通讯作者：
Alvarez TL
中科院分区：
文献类型：
--
作者：
Alvarez TL
目的：探讨近分离隐斜视与视差性聚散眼运动的关系。将聚散治疗前的会聚功能不全（CI）患者与（1）聚散治疗后的相同患者和（2）双眼正常对照（BNC）进行比较。方法：16名受试者进行了研究，12名BNC和4名CI。CI受试者的测量值在聚散眼球运动治疗前后18小时获得。用闪光Maddox杆技术测量近分离隐斜视。从4°对称视差聚散步刺激刺激聚散反应。通过独立分量分析（伊卡）计算了聚散度响应的峰值速度和融合起始分量（FIC）的大小。进行线性回归分析，研究作为近分离隐斜视的函数的聚散峰值速度，其中计算Pearson相关系数。结果如下：在聚散治疗前，CI受试者的会聚反应的平均值和一个标准差FIC幅度为0.29° ± 0.82，显著低于BNC的FIC幅度1.85° ± 0.84（p < 0.02）。配对t检验报告CI受试者在聚散治疗前的FIC和近分离隐斜视显著增加至1.49° ± 0.57（p < 0.04），并且在聚散治疗后变得较少外斜视至3.5Δ ± 1.9外斜视（p < 0.02）。近分离隐斜与会聚峰速度除以发散峰速度的聚散度比值呈显著相关（r = 0.87; p < 0.01）。结论：这些结果在理解聚散度治疗可能改变聚散度系统导致视觉症状持续减少的机制方面具有临床转化影响。
Purpose: This study examined the relationship between the near dissociated phoria and disparity vergence eye movements. Convergence insufficiency (CI) patients before vergence therapy were compared to: (1) the same patients after vergence therapy; and (2) binocularly normal controls (BNC). Methods: Sixteen subjects were studied—twelve BNC and four with CI. Measurements from the CI subjects were obtained before and after 18 h of vergence eye movement therapy. The near dissociated phoria was measured using the flashed Maddox rod technique. Vergence responses were stimulated from 4° symmetrical disparity vergence step stimuli. The peak velocity of the vergence response and the magnitude of the fusion initiating component (FIC) from an independent component analysis (ICA) were calculated. A linear regression analysis was conducted studying the vergence peak velocity as a function of the near dissociated phoria where the Pearson correlation coefficient was computed. Results: Before vergence therapy, the average with one standard deviation FIC magnitude of convergence responses from CI subjects was 0.29° ± 0.82 and significantly less than the FIC magnitude of 1.85° ± 0.84 for BNC (p < 0.02). A paired t-test reported that the FIC and near dissociated phoria before vergence therapy for CI subjects significantly increased to 1.49° ± 0.57 (p < 0.04) and became less exophoric to 3.5Δ ± 1.9 exo (p < 0.02) after vergence therapy. A significant correlation (r = 0.87; p < 0.01) was observed between the near dissociated phoria and the vergence ratio of convergence peak velocity divided by divergence peak velocity. Conclusion: The results have clinical translational impact in understanding the mechanism by which vergence therapy may be changing the vergence system leading to a sustained reduction in visual symptoms.