Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals
Changes in airway resistance induced by nasal inhalation of cold dry, dry, or moist air in normal individuals
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DOI：
10.1152/jappl.1996.81.4.1739
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发表时间：
1996-10-01
影响因子：
3.3
通讯作者：
Jammes, Y
中科院分区：
文献类型：
--
作者：
Fontanari, P;Burnet, H;Jammes, Y
在动物和哮喘患者中已经描述了由机械或刺激性刺激鼻子引起的鼻支气管反射。然而，很少有研究致力于鼻呼吸寒冷和干燥的空气或只有干燥或只有潮湿的空气对正常人的支气管炎控制的后果。本研究报告了在适度寒冷（-4或-10 ℃）和干燥[0.3%相对湿度（RH）]空气或23 ℃干燥（0.3% RH）或潮湿（97% RH）的室内空气的正常呼吸期间测量的中断阻力（Rint）的变化。鼻吸入冷（-4 ℃）干燥空气或仅吸入干燥空气在整个15分钟测试期间显著增加基线Rint值（分别为17%和21%）。当空气温度降低到-10摄氏度时，对寒冷的反应显着加剧（42%）。鼻麻醉或吸入胆碱能拮抗剂后，冷空气并没有引起Rint的变化。鼻腔吸入潮湿的室内空气没有影响。在三种测试试剂的经口呼吸期间没有测量到Rint变化。结论：正常人鼻粘膜冷受体或冷受体的激活可诱导保护性支气管收缩反应。
Nasopulmonary bronchomotor reflexes elicited by mechanical or irritant stimulation of the nose have been described in animals and asthmatic patients. However, few studies were devoted to the consequences of nasal breathing of cold and dry air or of only dry or only moist air on the bronchomotor control in normal individuals. The present study reported changes in interruption resistance (Rint) measured during eupneic breathing of moderately cold (-4 or -10 degrees C) and dry [0.3% relative humidity (RH)] air or of room air at 23 degrees C that is either dry (0.3% RH) or moist (97% RH). Nasal inhalation of cold (-4 degrees C) dry air or of only dry air significantly increased baseline Rint value (17 and 21%, respectively) throughout the 15-min test periods. The response to cold was significantly accentuated when the air temperature was lowered to -10 degrees C (42%). After nasal anesthesia or inhalation of a cholinergic antagonist, cold air did not induce a change in Rint. Nasal inhalation of moist room air had no effect. No Rint changes were measured during oral breathing of the three test agents. It is concluded that the activation of cold receptors or osmoreceptors in the nasal mucosa induces protective bronchoconstrictor responses in normal individuals.