From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues.
From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues.
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DOI：
10.1161/circresaha.116.308538
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发表时间：
2017-01-06
影响因子：
20.1
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Borovjagin AV;Ogle BM;Berry JL;Zhang J
目前用于工程化心血管细胞和组织的策略已经产生了各种复杂的工具，用于研究疾病机制，用于开发药物疗法，以及用于制造可能在未来临床使用中具有应用的组织等同物。这些努力的动机是需要将传统的二维（2D）细胞培养系统扩展到3D，以更准确地复制心血管结构的体内细胞和组织功能。微尺度设备和生物打印3D组织的发展开始取代传统的2D细胞培养和临床前动物研究，这些研究在历史上一直是药物和组织开发的标准。这些新方法适用于患者特异性诊断、治疗和组织再生。这些技术的出现也带来了在传统细胞培养和动物试验过时之前需要应对的技术挑战。3D人体组织结构的成功开发和验证将为心血管组织等效物的更经济有效和及时的翻译提供强大的新范例。
Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional two-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and pre-clinical animal studies that have historically been the standard for drug and tissue development. These new approaches lend themselves to patient-specific diagnostics, therapeutics, and tissue regeneration. The emergence of these technologies also carries technical challenges to be met before traditional cell culture and animal testing become obsolete. Successful development and validation of 3D human tissue constructs will provide powerful new paradigms for more cost effective and timely translation of cardiovascular tissue equivalents.