Evaluation of SOX9 Expression in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm
Evaluation of SOX9 Expression in Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm
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DOI：
10.1097/mpa.0b013e318269d281
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发表时间：
2013-04-01
期刊：
影响因子：
2.9
通讯作者：
Eguchi, Susumu
中科院分区：
文献类型：
--
作者：
Tanaka, Takayuki;Kuroki, Tamotsu;Eguchi, Susumu
目的：性别决定区 Y (SRY) 盒 9 (SOX9) 是发育所需的重要转录因子，与多种类型的癌症有关。性别决定区 Y 盒 9 从未与胰腺导管腺癌 (PDAC) 和胰腺导管内乳头状粘液性肿瘤 (IPMN) 有关。本研究旨在探讨SOX9与PDAC以及SOX9与IPMN之间的关系。方法：收集55例PDAC患者和68例IPMN患者的手术标本，采用SOX9免疫组化分析。结果：正常胰腺中SOX9阳性细胞占总胰管上皮细胞的比例为82.7%。另一方面，PDAC中的SOX9阳性率为0.8%。正常胰腺和PDAC之间存在显着差异（P = 0.0002）。在IPMN中，SOX9阳性率随着肿瘤进展而逐渐下降，观察到以下阳性率：导管内乳头状粘液腺瘤（66.3％）；非浸润性导管内乳头状粘液癌（46.3%）；微创导管内乳头状粘液癌（30.5%）；起源于导管内乳头状粘液癌的浸润性癌（2.3%）。各组之间存在显着差异（P < 0.05）。结论：我们的数据表明SOX9可能有助于PDAC和IPMN的癌变。
Objectives: Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The aim of this study was to investigate the relationship between SOX9 and PDAC and that between SOX9 and IPMN.Methods: Surgical specimens were obtained from 55 patients with PDAC and 68 patients with IPMN and were investigated using SOX9 immunohistochemical analysis.Results: The rate of SOX9 positive cells to total pancreatic duct epithelial cells in a normal pancreas was 82.7%. On the other hand, the SOX9 positive rate in PDAC was 0.8%. There was a significant difference between the normal pancreas and PDAC (P = 0.0002). In IPMN, the SOX9 positive rate gradually decreased according to tumor progression, with the following rates observed: intraductal papillary mucinous adenoma (66.3%); noninvasive intraductal papillary mucinous carcinoma (46.3%); minimally invasive intraductal papillary mucinous carcinoma (30.5%); and invasive carcinoma originating in intraductal papillary mucinous carcinoma (2.3%). There were significant differences between each group (P < 0.05).Conclusions: Our data suggested that SOX9 might contribute to carcinogenesis in PDAC and IPMN.