Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study
Dietary fibre intake and ischaemic heart disease mortality: the European Prospective Investigation into Cancer and Nutrition-Heart study
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DOI：
10.1038/ejcn.2012.51
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发表时间：
2012-08-01
影响因子：
4.7
通讯作者：
Riboli, E.
中科院分区：
文献类型：
--
作者：
Crowe, F. L.;Key, T. J.;Riboli, E.
背景/目的：来自前瞻性研究的证据一致显示膳食纤维摄入量与缺血性心脏病（IHD）风险之间存在负相关，但不同食物来源的膳食纤维对IHD风险的影响是否不同尚不清楚。本研究的目的是评估协会的总膳食纤维和食物来源与IHD死亡率在欧洲前瞻性调查癌症和营养心脏study.SUBJECTS/METHODS：参与者是306 331名男性和女性来自8个欧洲国家。膳食纤维的摄入量进行了评估，使用中心或国家特定的饮食问卷和校准使用24小时饮食recall.RESULTS：平均随访11.5年后，有2381 IHD死亡的参与者没有心血管疾病的基线。膳食纤维的校准摄入量与IHD死亡率呈负相关;每10 g/天与15%的风险降低相关（相对风险（RR）0.85; 95%置信区间（CI）：0.73-0.99，P = 0.031）。不同食物来源的膳食纤维与缺血性心脏病死亡率的相关性没有差异;谷物纤维摄入量每增加5克/天，RR为0.91（CI：0.82-1.01），每摄入2.5g水果纤维的RR为0.94（CI：0.88-1.01），每摄入2.5 g/d植物纤维的RR为0.90（95% CI：0.76-1.07）。结论：膳食纤维摄入量越高，致命性IHD的风险越低，与纤维摄入量相比，与IHD的相关性没有明显差异谷物、水果或蔬菜。
BACKGROUND/OBJECTIVES: Evidence from prospective studies is consistent in showing an inverse association between dietary fibre intake and risk of ischaemic heart disease (IHD), but whether dietary fibre from various food sources differ in their effect on IHD risk is less clear. The objective of this study was to assess the associations of total and food sources of dietary fibre with IHD mortality in the European Prospective Investigation into Cancer and Nutrition-Heart study.SUBJECTS/METHODS: Participants were 306 331 men and women from eight European countries. Dietary fibre intake was assessed using centre or country-specific diet questionnaires and calibrated using a 24-h diet recall.RESULTS: After an average follow-up of 11.5 years, there were 2381 IHD deaths among participants without cardiovascular disease at baseline. The calibrated intake of dietary fibre was inversely related with IHD mortality; each 10 g/day was associated with a 15% lower risk (relative risk (RR) 0.85; 95% confidence interval (CI): 0.73-0.99, P = 0.031). There was no difference in the associations of the individual food sources of dietary fibre with the risk of IHD mortality; RR for each 5 g/day higher cereal fibre intake was 0.91 (CI: 0.82-1.01), RR for each 2.5 g/day fruit fibre intake was 0.94 (CI: 0.88-1.01) and RR for each 2.5 g/day vegetable fibre intake was 0.90 (95% CI: 0.76-1.07).CONCLUSION: A higher consumption of dietary fibre is associated with a lower risk of fatal IHD with no clear difference in the association with IHD for fibre from cereals, fruits or vegetables.