Does sleep restore the topology of functional brain networks?
Does sleep restore the topology of functional brain networks?
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DOI：
10.1002/hbm.21455
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发表时间：
2013-02-01
影响因子：
4.8
通讯作者：
Stam, Cornelis J.
中科院分区：
文献类型：
--
作者：
Koenis, Maria M. G.;Romeijn, Nico;Stam, Cornelis J.
以前的研究表明，健康的解剖和功能大脑网络具有小世界的属性，在大脑疾病时变得不那么理想。在睡眠中，起作用的大脑网络变得更像小世界。在这里，我们测试了一种假设，即在睡眠剥夺(SD)后，清醒时的大脑功能网络变得不那么理想。对8名健康青年受试者分别在睡眠正常和夜间睡眠后，分别在闭眼和睁眼休息状态下记录脑电(EEG)5次。用同步似然(SL)和相位滞后指数(PLI)确定总体同步。根据这些耦合强度矩阵，计算了归一化聚类系数C(局部聚类的度量)和路径长度L(全局积分的度量)。将这两个量度除以相应的随机控制网的C-S和L-S值进行归一化处理。闭眼安静时，SD降低了α频段C/C-S和L/L-S，降低了α频段C/C-S。相比之下，SD组睁眼安静时C/C-S和L/L-S的伽马频段增加。这些网络属性的变化与睡眠剥夺导致的持续性注意力简单反应时任务中的表现缺陷有关，这表明它们具有功能性相关性。结果表明，SD导致了一个更随机的阿尔法耦合网络和一个更有序的伽马耦合网络。目前的研究表明，SD导致大脑功能网络拓扑结构的频率特异性变化，支持睡眠在维持最佳功能网络中的作用。Hum Brain Mapp，2013年。(C)2011年威利期刊公司。
Previous studies have shown that healthy anatomical as well as functional brain networks have small-world properties and become less optimal with brain disease. During sleep, the functional brain network becomes more small-world-like. Here we test the hypothesis that the functional brain network during wakefulness becomes less optimal after sleep deprivation (SD). Electroencephalography (EEG) was recorded five times a day after a night of SD and after a night of normal sleep in eight young healthy subjects, both during eyes-closed and eyes-open resting state. Overall synchronization was determined with the synchronization likelihood (SL) and the phase lag index (PLI). From these coupling strength matrices the normalized clustering coefficient C (a measurement of local clustering) and path length L (a measurement of global integration) were computed. Both measures were normalized by dividing them by their corresponding C-s and L-s values of random control networks. SD reduced alpha band C/C-s and L/L-s and theta band C/C-s during eyes-closed resting state. In contrast, SD increased gamma-band C/C-s and L/L-s during eyes-open resting state. Functional relevance of these changes in network properties was suggested by their association with sleep deprivation-induced performance deficits on a sustained attention simple reaction time task. The findings indicate that SD results in a more random network of alpha-coupling and a more ordered network of gamma-coupling. The present study shows that SD induces frequency-specific changes in the functional network topology of the brain, supporting the idea that sleep plays a role in the maintenance of an optimal functional network. Hum Brain Mapp, 2013. (C) 2011 Wiley Periodicals, Inc.