Acetic acid improves identification of remnant islands of Barrett's epithelium after endoscopic therapy
Acetic acid improves identification of remnant islands of Barrett's epithelium after endoscopic therapy
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DOI：
10.1016/s0016-5107(98)70253-6
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发表时间：
1998-06-01
影响因子：
7.7
通讯作者：
Herrera, I
中科院分区：
文献类型：
--
作者：
Guelrud, M;Herrera, I
背景：多年来，阴道镜检查时在子宫颈上灌注乙酸已被用于突出发育不良区域，从而提高获得靶向活检标本的能力。作为一项正在进行的Barrett食管多极电凝试验的一部分，我们试图开发一种简单的技术来识别治疗后残留的小岛屿特化柱状上皮。方法：在连续21例患者中，先用喷雾导管向食管远端喷洒5 ~ 10 mt 1.5%醋酸，然后立即喷洒50 mt自来水。结果：最初，食管和胃上皮呈白色。2 ~ 3分钟后，食管鳞状黏膜仍呈白色，柱状上皮变红。残留的巴雷特上皮岛状突起呈白色边缘。结论：醋酸滴注可提高Barrett食管内镜治疗后柱状上皮小岛屿或难以区分的残余岛的检测能力。这种方法安全、快速、廉价。
Background: Instillation of acetic acid onto the uterine cervix at colposcopy has been used fear many years to highlight dysplastic areas and thereby enhance the ability to obtain targeted biopsy specimens. As part of an ongoing trial of multipolar electrocoagulation for Barrett's esophagus, we sought to develop a simple technique to identify small islands of residual specialized columnar epithelium after treatment.Methods: In 21 consecutive patients, 5 to 10 mt of 1.5% acetic acid was sprayed onto the distal esophagus using a spray catheter, followed immediately by spraying 50 mt of tap water.Results: Initially, a whitish coloration developed in both esophageal and gastric epithelia. After 2 to 3 minutes, the esophageal squamous mucosa remained white but the columnar epithelium became reddish. Remnant islands of Barrett's epithelium were outlined by a white rim.Conclusion: Acetic acid instillation enhances the ability to detect small or indistinguishable remnant islands of columnar epithelium after endoscopic treatment of Barrett's esophagus. This method is safe, rapid, and inexpensive.