Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity
Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity
复制标题
三芳基硼掺杂并苯噻吩作为有机声敏剂，用于低光毒性的高效声动力治疗
DOI：
10.1002/adma.202206594
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发表时间：
2022
影响因子：
29.4
通讯作者：
Chen, Pangkuan
中科院分区：
文献类型：
--
作者：
Liu, Kanglei;Jiang, Zhenqi;Zhao, Fenggui;Wang, Weizhi;Jäkle, Frieder;Wang, Nan;Tang, Xiaoying;Yin, Xiaodong;Chen, Pangkuan
有效的有机声敏剂的开发是声动力学治疗（SDT）在癌症治疗领域的关键。在此，提出了一种基于三芳基硼掺杂的苊骨架开发有效有机声敏剂的新策略。硼与直链并噻吩的连接降低了最低未占分子轨道（LUMO）能量，导致红移的吸收和发射。在用两亲性聚合物DSPE-mPEG 2000包封后，发现纳米结构的BAnTh-NPs和BTeTh-NPs（BAnTh和BTeTh的纳米颗粒）在超声（US）照射下在水溶液中显示出有效的羟基自由基（·OH）产生，几乎没有光毒性，这可以克服O2依赖性SDT的缺点并避免潜在的皮肤光毒性问题。体外和体内治疗结果证实，硼掺杂的并苯噻吩作为声敏剂能够实现高SDT效率，具有低的光毒性和良好的生物相容性，表明硼官能化并苯是一种有前途的策略，可用于SDT的有机声敏剂。
The development of efficient organic sonosensitizers is crucial for sonodynamic therapy (SDT) in the field of cancer treatment. Herein, a new strategy for the development of efficient organic sonosensitizers based on triarylboron‐doped acenethiophene scaffolds is presented. The attachment of boron to the linear acenethiophenes lowers the lowest unoccupied molecular orbital (LUMO) energy, resulting in redshifted absorptions and emissions. After encapsulation with the amphiphilic polymer DSPE‐mPEG2000, it is found that the nanostructured BAnTh‐NPs and BTeTh‐NPs (nanoparticles of BAnTh and BTeTh) shows efficient hydroxyl radical (•OH) generation under ultrasound (US) irradiation in aqueous solution with almost no phototoxicity, which can overcome the shortcomings of O2‐dependent SDT and avoid the potential cutaneous phototoxicity issue. In vitro and in vivo therapeutic results validate that boron‐doped acenethiophenes as sonosensitizers enable high SDT efficiency with low phototoxicity and good biocompatibility, indicating that boron‐functionalization of acenes is a promising strategy toward organic sonosensitizers for SDT.