DISTRIBUTION OF BINDING-SITES FOR I-125-LABELED ALPHA-BUNGAROTOXIN IN NORMAL AND DEAFFERENTED ANTENNAL LOBES OF MANDUCA-SEXTA
DISTRIBUTION OF BINDING-SITES FOR I-125-LABELED ALPHA-BUNGAROTOXIN IN NORMAL AND DEAFFERENTED ANTENNAL LOBES OF MANDUCA-SEXTA
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DOI：
10.1073/pnas.76.1.499
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
OSMOND, BC
中科院分区：
文献类型：
--
作者：
HILDEBRAND, JG;HALL, LM;OSMOND, BC
用~(125)I标记的α-银环蛇毒素测定了六纹夜蛾正常触角叶和慢性去传入触角叶中乙酰胆碱受体的分布。毒素结合部位局限于正常脑叶神经束中的突触区域和去传入脑叶中这些区域的雏形。显然，受体可以在昆虫中枢神经系统中独立于正常突触的影响而发展。
125I-Labeled .alpha.-bungarotoxin was used to determine the distribution of putative acetylcholine receptors in normal and chronically deafferented antennal lobes in the brain of the moth M. sexta. Toxin-binding sites were confined to synaptic regions in the neuropil of normal lobes and to rudiments of these regions in deafferented lobes. Receptors apparently can develop in the insect CNS independently of normal synaptic influences.