Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection.
Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection.
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DOI：
10.3390/microorganisms8091298
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发表时间：
2020-08-25
期刊：
影响因子：
4.5
通讯作者：
Jung YJ
中科院分区：
文献类型：
--
作者：
Lee HJ;Woo Y;Hahn TW;Jung YM;Jung YJ
吞噬作用是先天性免疫防御中的基本机制，并且在维持稳态以消除凋亡细胞或微生物（如结核分枝杆菌、肠道沙门氏菌、化脓性链球菌和嗜肺军团菌）中是基本机制。在通过吞噬作用内化微生物病原体后，吞噬体经历一系列“成熟”步骤，以形成逐渐酸化的隔室，随后与溶酶体融合以发育成吞噬溶酶体并有效地消除入侵的病原体。通过这种机制，吞噬细胞（包括巨噬细胞、中性粒细胞和树突状细胞）参与微生物病原体的加工和抗原提呈给T细胞以启动适应性免疫反应。因此，吞噬作用在先天免疫和适应性免疫之间起着桥梁作用。然而，细胞内细菌已经进化出多种策略来在宿主中生存和复制。在这篇综述中，我们描述了在吞噬过程中的顺序阶段。我们还讨论了病原体在细胞内细菌感染过程中用于调节吞噬体成熟的免疫逃避策略，并指出这些策略可能用于开发感染性疾病的潜在治疗策略。
Phagocytosis is an essential mechanism in innate immune defense, and in maintaining homeostasis to eliminate apoptotic cells or microbes, such as Mycobacterium tuberculosis, Salmonella enterica, Streptococcus pyogenes and Legionella pneumophila. After internalizing microbial pathogens via phagocytosis, phagosomes undergo a series of ‘maturation’ steps, to form an increasingly acidified compartment and subsequently fuse with the lysosome to develop into phagolysosomes and effectively eliminate the invading pathogens. Through this mechanism, phagocytes, including macrophages, neutrophils and dendritic cells, are involved in the processing of microbial pathogens and antigen presentation to T cells to initiate adaptive immune responses. Therefore, phagocytosis plays a role in the bridge between innate and adaptive immunity. However, intracellular bacteria have evolved diverse strategies to survive and replicate within hosts. In this review, we describe the sequential stages in the phagocytosis process. We also discuss the immune evasion strategies used by pathogens to regulate phagosome maturation during intracellular bacterial infection, and indicate that these might be used for the development of potential therapeutic strategies for infectious diseases.
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影响因子：
4.8
作者：
Berge, A;Kihlberg, BM;Bjorck, L
通讯作者：
Bjorck, L
Fcgamma受体介导的巨噬细胞中缺乏SRC家族酪氨酸激酶HCK，FGR和Lyn的吞噬作用。
影响因子：
15.3
作者：
Fitzer-Attas, C J;Lowry, M;Crowley, M T;Finn, A J;Meng, F;DeFranco, A L;Lowell, C A
通讯作者：
Lowell, C A
DOI：
10.1084/jem.20031237
发表时间：
2004-01-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Doyle SE;O'Connell RM;Miranda GA;Vaidya SA;Chow EK;Liu PT;Suzuki S;Suzuki N;Modlin RL;Yeh WC;Lane TF;Cheng G
通讯作者：
Cheng G
影响因子：
5.4
作者：
Duus, Karen;Hansen, Erik W.;Houen, Gunnar
通讯作者：
Houen, Gunnar
影响因子：
15.9
作者：
Dahl, Morten;Bauer, Alison K.;Kobzik, Lester
通讯作者：
Kobzik, Lester