Prevalence of hyperuricaemia in an Eastern Chinese population: a cross-sectional study
Prevalence of hyperuricaemia in an Eastern Chinese population: a cross-sectional study
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中国东部人群高尿酸血症的患病率：一项横断面研究
DOI：
10.1136/bmjopen-2019-035614
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发表时间：
2020-01-01
期刊：
影响因子：
2.9
通讯作者：
Lu, Yingli
中科院分区：
文献类型：
--
作者：
Han, Bing;Wang, Ningjian;Lu, Yingli
在过去的十年里，中国的特点是大规模的城市化和快速的经济增长。本研究的目的是进一步调查高尿酸血症（HUA）在中国东部人群中的患病率。设计横断面研究。中国华东地区代谢性疾病患病率及危险因素的研究。研究对象在本研究中，从中国东部22个地点招募了12 770名居民。最终纳入9225例受试者。主要观察指标：检测血清尿酸（UA）、空腹血糖（FPG）、糖化血红蛋白（Hb）等代谢指标。还测量了腰围、体重、身高和血压。从受试者中收集有关吸烟、饮酒、教育的问卷。HUA定义为男性血清UA> 420 µ mol/L，女性> 360 µ mol/L。结果华东地区人群HUA患病率为11.3%（9.9，12.7），男性20.7%（17.7，23.7），女性5.6%（4.3，6.7）。城市人群HUA患病率高于农村人群（12.9%比10.8%，P <0.01）。男性和女性的HUA患病率分别与年龄呈负相关和正相关。高体重指数的居民有较高的HUA患病率。Logistic回归分析显示，男性、城市居民、总胆固醇、甘油三酯、超重、肥胖、收缩压、低经济状况与HUA独立相关。结论中国东部人群HUA的估计患病率为11.3%（9.9，12.7），男性和女性分别为20.7%（17.7，23.7）和5.6%（4.3，6.7）。HUA已逐渐成为中国重要的公共卫生问题。试验注册号ChiCTR-ECS-14005052。
Objectives In the past decade, China has been characterised by large-scale urbanisation as well as rapid economic growth. The aim of this study was to further investigate the prevalence of hyperuricaemia (HUA) in an Eastern Chinese population. Design Cross-sectional study. Setting Survey of Prevalence in East China of Metabolic Diseases and Risk Factors China study. Participants In this study, 12 770 residents from 22 sites in Eastern China were recruited. Finally, 9225 subjects were included. Main outcome measures The serum levels of uric acid (UA), fasting plasma glucose (FPG), glycated haemoglobin and other metabolic parameters were tested. Waist circumference, weight, height and blood pressure were also measured. Questionnaires regarding smoking, drinking, education were collected from the subjects. HUA was defined as serum UA >420 µmol/L for men and >360 µmol/L for women. Results The prevalence of HUA in this Eastern Chinese population was 11.3% (9.9, 12.7) overall, 20.7% (17.7, 23.7) in men and 5.6% (4.3, 6.7) in women. The prevalence of HUA in urban subjects was higher than that in rural subjects (12.9 vs 10.8%, p<0.01). The prevalence of HUA was negatively and positively associated with age in men and women, respectively. Residents with high body mass index levels had a higher prevalence of HUA. In the logistic regression analysis, male sex, urban residency, total cholesterol, triglyceride, overweight, obesity, systolic blood pressure and low economic status were independently correlated with HUA. Conclusions The estimated prevalence of HUA in this Eastern Chinese population was 11.3% (9.9, 12.7) overall and 20.7% (17.7, 23.7) and 5.6% (4.3, 6.7) in men and women, respectively. HUA has gradually become an important public health issue in China. Trial registration number ChiCTR-ECS-14005052.