Copper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils
Copper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils
复制标题
铜催化邻氨基苯甲醚与甲基酮的反应：邻氨基苯甲醚的位点选择性 C5-二羰基化
DOI：
10.1002/adsc.202001334
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发表时间：
2021
影响因子：
5.4
通讯作者：
Wu An-Xin
中科院分区：
文献类型：
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作者：
Zhuang Shi-Yi;Tang Yong-Xing;He Cai;Chen Xiang-Long;Xue Wei-Jian;Wu Yan-Dong;Wu An-Xin
已经开发了铜催化的邻氨基苯甲酸的位点选择性C5-二羰基化反应，用于使用甲基酮作为市售羰基化试剂合成1，2-二羰基化合物。该方法代表了实施邻氨基苯的C5-二羰基化的第一个实施例，其涉及氧化Csp 3-H/Csp 2-H交叉偶联反应沿着热释N-O键断裂。
A copper‐catalyzed site‐selective C5‐dicarbonylation reaction of anthranils has been developed for synthesis of 1,2‐dicarbonyl compounds using methyl ketone as a commercially available carbonylation reagent. This process represents the first example to implement the C5‐dicarbonylation of anthranils, which involves an oxidative Csp3‐H/Csp2‐H cross‐coupling reaction along with thermolytic N−O bond cleavage.