Early-life programming of aging and longevity - The idea of high initial damage load (the HIDL hypothesis)
Early-life programming of aging and longevity - The idea of high initial damage load (the HIDL hypothesis)
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DOI：
10.1196/annals.1297.091
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Gavrilova, NS
中科院分区：
文献类型：
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作者：
Gavrilov, LA;Gavrilova, NS
在这项研究中，我们测试了高初始损伤负荷（HIDL）假说的预测，这是一种科学观点，认为生物体的早期发育会产生异常高的初始损伤负荷，这与随后在整个成年生活中积累的衰老相关的退化量相当。这一假说预测，即使在优化早期发育过程方面取得很小的进展，也可能导致在晚年生活中显著预防许多疾病，推迟与衰老有关的发病率和死亡率，并显着延长健康寿命。
In this study, we test the predictions of the high initial damage load (HIDL) hypothesis, a scientific idea that early development of living organisms produces an exceptionally high load of initial damage, which is comparable with the amount of subsequent aging-related deterioration accumulating during the rest of the entire adult life. This hypothesis predicts that even small progress in optimizing the early-developmental processes can potentially result in a remarkable prevention of many diseases in later life, postponement of aging-related morbidity and mortality, and significant extension of healthy life span.