Anti-membrane Antibodies Persist at Least One Year and Discriminate Between Past Coronavirus Disease 2019 Infection and Vaccination
Anti-membrane Antibodies Persist at Least One Year and Discriminate Between Past Coronavirus Disease 2019 Infection and Vaccination
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DOI：
10.1093/infdis/jiac263
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发表时间：
2022-06-27
影响因子：
6.4
通讯作者：
Shelef, Miriam A.
中科院分区：
文献类型：
--
作者：
Amjadi, Maya F.;Adyniec, Ryan R.;Shelef, Miriam A.
抗膜抗体可持续至少1年，是过去新冠肺炎感染的敏感和特异标记物。此外，抗膜抗体和抗刺抗体一起可以区分新冠肺炎的恢复期、疫苗接种和幼稚状态。背景过去的冠状病毒病2019年(新冠肺炎)感染对个人和人群健康的影响正在出现，但准确识别远程感染是一个挑战。在接种疫苗和感染后，抗尖峰抗体上升，抗核衣壳抗体迅速下降。方法对新冠肺炎幼稚、免疫接种和恢复期受试者进行抗膜抗体检测，以确定抗膜抗体是否持续存在并准确检测远处感染。结果抗膜抗体可持续至少1年，是既往新冠肺炎感染的敏感而特异的标志物。结论抗膜抗体和抗棘波抗体联合检测可区分新冠肺炎的恢复期、疫苗接种和幼稚状态，促进公共卫生和研究。
Antimembrane antibodies persist for at least 1 year and are a sensitive and specific marker of past COVID-19 infection. Also, antimembrane and antispike antibodies together can differentiate between COVID-19 convalescent, vaccinated, and naive states.Background The consequences of past coronavirus disease 2019 (COVID-19) infection for personal and population health are emerging, but accurately identifying distant infection is a challenge. Anti-spike antibodies rise after both vaccination and infection and anti-nucleocapsid antibodies rapidly decline. Methods We evaluated anti-membrane antibodies in COVID-19 naive, vaccinated, and convalescent subjects to determine if they persist and accurately detect distant infection. Results We found that anti-membrane antibodies persist for at least 1 year and are a sensitive and specific marker of past COVID-19 infection. Conclusions Thus, anti-membrane and anti-spike antibodies together can differentiate between COVID-19 convalescent, vaccinated, and naive states to advance public health and research.