Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe
Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern Europe
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DOI：
10.1080/15287390701798685
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Moore, L. E.
中科院分区：
文献类型：
--
作者：
Karami, S.;Brennan, P.;Moore, L. E.
以前的研究调查了维生素D摄入量和癌症风险的作用。肾脏是维生素D代谢、活性和钙稳态的主要器官;因此，假设膳食维生素D摄入量和维生素D受体（VDR）基因多态性可能会改变肾细胞癌（RCC）的风险。在中欧和东欧进行的一项以医院为基础的病例对照研究中，对925例肾细胞癌病例和1192例对照者中三种常见的VDR基因多态性（BsmI、FokI、TaqI）进行了评价。未观察到与RCC风险的总体相关性;然而，亚组分析显示，按诊断的中位年龄和癌症家族史分层后存在相关性。在60岁以上的受试者中，与FF基因型受试者相比，FokI单核苷酸多态性（SNP）中f等位基因携带者（Ff基因型OR = 0.61，ff基因型OR = 0.74）的风险降低（P趋势= 0.04; P相互作用= 0.004）。具有BB BsmI基因型和阳性癌症家族史的受试者与具有bb等位基因的受试者相比具有较低的风险（OR = 0.60; 95%CI：0.33-1.1; P趋势= 0.05）。当考虑到维生素D或钙的饮食来源时，基因型与这些亚组的关联没有改变。VDR基因遗传变异的进一步研究是必要的。
Previous studies investigated the role of vitamin D intake and cancer risk. The kidney is a major organ for vitamin D metabolism, activity, and calcium homeostasis; therefore, it was hypothesized that dietary vitamin D intake and polymorphisms in the vitamin D receptor (VDR) gene may modify renal cell carcinoma (RCC) risk. Three common VDR gene polymorphisms (BsmI, FokI, TaqI) were evaluated among 925 RCC cases and 1192 controls enrolled in a hospital-based case-control study conducted in Central and Eastern Europe. Overall associations with RCC risk were not observed; however, subgroup analyses revealed associations after stratification by median age of diagnosis and family history of cancer. Among subjects over 60 yr, reduced risks were observed among carriers of the f alleles in the FokI single-nuceotide polymorphism (SNP) (odds ratio [OR] = 0.61 for Ff and OR = 0.74 for ff genotypes) compared to subjects with the FF genotype (P trend = 0.04; P interaction = 0.004). Subjects with the BB BsmI genotype and a positive family history of cancer had lower risk compared to subjects with the bb allele (OR = 0.60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted.