Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature

Measuring robustness of brain networks in autism spectrum disorder with Ricci curvature
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用里奇曲率测量自闭症谱系障碍大脑网络的鲁棒性

DOI:
10.1101/722025
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发表时间:
2020
期刊:
Scientific report
影响因子:
--
通讯作者:
A. Simhal, K. Carpenter
A. Simhal, K. Carpenter
中科院分区:
--
文献类型:
--
作者:
A. Simhal, K. Carpenter

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奥利维尔-里奇曲率(Ollivier-Ricci curvature)是一种用于测量网络中连接的鲁棒性的方法。在这项工作中,我们使用曲率来测量自闭症谱系障碍(ASD)儿童大脑网络鲁棒性的变化。在一项开放标签临床试验中,ASD参与者接受单次自体脐带血输注,作为其临床结局指标的一部分,在输注前后进行弥散MRI成像。通过使用Ricci曲率来衡量鲁棒性的变化,我们量化了大脑网络中的局部和全局变化及其与输液的潜在关系。我们的研究结果发现了与ASD相关的区域之间连接的曲率变化,这些变化通过传统的大脑网络分析无法检测到。
Ollivier–Ricci curvature is a method for measuring the robustness of connections in a network. In this work, we use curvature to measure changes in robustness of brain networks in children with autism spectrum disorder (ASD). In an open label clinical trials, participants with ASD were administered a single infusion of autologous umbilical cord blood and, as part of their clinical outcome measures, were imaged with diffusion MRI before and after the infusion. By using Ricci curvature to measure changes in robustness, we quantified both local and global changes in the brain networks and their potential relationship with the infusion. Our results find changes in the curvature of the connections between regions associated with ASD that were not detected via traditional brain network analysis.
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