Inter- and Intra-Mouse Variability in Odor Preferences Revealed in an Olfactory Multiple-Choice Test
Inter- and Intra-Mouse Variability in Odor Preferences Revealed in an Olfactory Multiple-Choice Test
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DOI：
10.1037/bne0000233
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发表时间：
2018-04-01
影响因子：
1.9
通讯作者：
Wesson, Daniel W.
中科院分区：
文献类型：
--
作者：
Jagetia, Sonum;Milton, Adrianna J.;Wesson, Daniel W.
动物在感官刺激之间进行选择，这是一种高度复杂的行为，包括检测、辨别。偏好。和记忆过程。据报道，啮齿动物对某些气味表现出强烈的偏好，例如，在选择可能的配偶或食物时。与对这些和其他“行为学相关”气味的反应明显的稳健性形成对比的是，对于在啮齿动物生态位中没有明显作用的气味，即所谓的“非行为学相关”气味，人们对行为的稳健性知之甚少。我们开发了一种监测小鼠戳鼻子行为的设备，并使用该设备来探索连续几天在不同气味之间以及在小鼠体内选择不同气味的流行率和稳定性。在嗅觉多项选择测试中，小鼠被测试了一组与行为学相关或非行为学相关的气味。在整个老鼠群体中观察到了对非行为学相关气味的显著偏好，对某些气味的调查持续时间比对另一些气味的调查持续时间更长。然而，我们发现这些反应在小鼠之间存在很大的变异性，而且在测试的几天中，小鼠对这些气味的反应甚至不同。与行为学相关的气味测试显示，对这些气味的反应在不同的小鼠中也是不同的，但在单个小鼠中，反应是某种程度上稳定的。这项工作建立了一种用于监测气味调查、选择和偏好行为的嗅觉多项选择测试，并应用该仪器评估了小鼠之间和小鼠内气味偏好选择的稳定性。这些结果表明，通过测量选择行为来分析气味偏好是不同的。
Animals choose between sensory stimuli, a highly complex behavior which includes detection, discrimination. preference. and memory processes. Rodents are reported to display robust preferences for some odors, for instance, in the context of choosing among passible mates or food items. In contrast to the apparent robustness of responses toward these and other "ethologically relevant" odors, little is known about the robustness of behaviors toward odors which have no overt role in the rodent ecological niche, so-called "nonethologically relevant" odors. We developed an apparatus for monitoring the nose-poking behavior of mice and used this apparatus to explore the prevalence and stability of choices among different odors both across mice, and within mice over successive days. Mice were tested with a panel of either ethologically relevant or nonethologically relevant odors in an olfactory multiple-choice test. Significant preferences to nonethologically relevant odors were observed across the population of mice, with longer investigation durations to some odors more than to others. However, we found substantial inter-mouse variability in these responses, and that responses to these odors even varied within mice across days of testing.. Tests with ethologically relevant odors revealed that responses toward these odors were also variable across mice, but within individual mice, responses were somewhat stable. This work establishes an olfactory multiple-choice test for monitoring odor investigation, choice, and preference behaviors and the application of this apparatus to assess across- and within-mouse odor-preference choice stability. These results highlight that odor preferences, as assayed by measuring choice behaviors, are variable.