Behavioral comparison of 4 and 6 month-old Ts65Dn mice: Age-related impairments in working and reference memory
Behavioral comparison of 4 and 6 month-old Ts65Dn mice: Age-related impairments in working and reference memory
复制标题
DOI：
10.1016/s0166-4328(02)00275-9
复制
发表时间：
2003-01-22
影响因子：
2.7
通讯作者：
Granholm, ACE
中科院分区：
文献类型：
--
作者：
Hunter, CL;Bimonte, HA;Granholm, ACE
Ts65Dn小鼠的鼠16号染色体的一个区段与唐氏综合征（DS）中受影响的人21号染色体上的基因区段相似，是部分三体的。这些动物表现出认知缺陷、神经化学失衡和胆碱能变性，类似于DS和早发性阿尔茨海默病的改变。Ts65Dn小鼠基底前脑胆碱能表型的丧失开始于大约6个月大，可能是由于神经营养系统功能不正常。我们比较了4个月和6个月大的Ts65Dn小鼠在水逃逸径向臂迷宫任务，调查工作和参考记忆之前和之后的报告发作胆碱能下降。与年龄匹配的对照组相比，4个月和6个月大的Ts65Dn小鼠表现出受损的表现。然而，年轻的Ts65Dn小鼠显示出学习所有工作和参考记忆措施的能力，而年长的Ts65Dn小鼠则没有。随着工作记忆负荷的增加，Ts65Dn小鼠未能保持性能，并且处理增加的工作记忆负荷的能力也随着年龄的增长而减弱。总的来说，这些数据表明，在Ts65Dn小鼠中，认知功能的主要改变发生在4至6个月的年龄之间。(C)2002 Elsevier Science B.V.保留所有权利。
Ts65Dn mice are partially trisomic for a segment of murine chromosome 16 similar to the gene segment on human chromosome 21 affected in Down's syndrome (DS). These animals display cognitive deficits, neurochemical imbalances, and cholinergic degeneration resembling alterations in DS and early onset Alzheimer's disease. The loss of basal forebrain cholinergic phenotype in Ts65Dn mice begins at approximately 6 months of age and may be due to an improperly functioning neurotrophic system. We compared 4 and 6 month-old Ts65Dn mice in a water-escape radial-arm maze task to investigate working and reference memory before and after the reported onset of cholinergic decline. Both 4 and 6 month-old Ts65Dn mice exhibited impaired performance compared to age-matched controls. However, the younger Ts65Dn mice displayed the capability to learn all working and reference memory measures, while the older Ts65Dn mice did not. Ts65Dn mice failed to maintain performance as working memory load increased, and the ability to handle an increasing working memory load also diminished with age. Collectively, these data suggest that major alterations in cognitive function occur in Ts65Dn mice between the ages of 4 and 6 months. (C) 2002 Elsevier Science B.V. All rights reserved.