Effect of Schistosomiasis and Soil-Transmitted Helminth Infections on Physical Fitness of School Children in Cote d'Ivoire
Effect of Schistosomiasis and Soil-Transmitted Helminth Infections on Physical Fitness of School Children in Cote d'Ivoire
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DOI：
10.1371/journal.pntd.0001239
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发表时间：
2011-07-01
影响因子：
3.8
通讯作者：
Utzinger, Juerg
中科院分区：
文献类型：
--
作者：
Mueller, Ivan;Coulibaly, Jean T.;Utzinger, Juerg
背景资料：血吸虫病和土壤传播的蠕虫病是撒哈拉以南非洲的重要公共卫生问题，导致营养不良、贫血以及身体和认知发育迟缓。然而，这些疾病对身体健康的影响仍有待确定。方法：我们调查了血吸虫病，土壤传播的蠕虫病和儿童的身体表现之间的关系，控制潜在的混淆疟原虫。感染和环境参数（即，环境空气温度和湿度）。对科特迪瓦156名7-15岁的学龄儿童进行了横断面调查。每个孩子有两个粪便和两个尿液样本检查蠕虫卵显微镜。此外，儿童接受了临床检查，进行了疟原虫检测。感染的快速诊断测试，并进行了最大多级20米穿梭跑测试，以评估他们的最大摄氧量（VO 2最大值）作为身体健康的代理。主要发现：血吸虫，疟原虫属，曼氏血吸虫、钩虫、蛔虫感染率分别为85.3%、71.2%、53.8%、13.5%和1.3%。单、双、三、四和五种细菌感染的儿童的最大摄氧量分别为52.7、53.1、52.2、52.6和55.6 ml kg（-1）min（-1）。无寄生虫感染儿童的最大摄氧量为53.5 ml kg（-1）min（-1）。任何组之间均未检测到统计学显著差异。多变量分析显示，VO 2 max受性别影响（参考：女性，coef. = 4.02，p
Background: Schistosomiasis and soil-transmitted helminthiasis are important public health problems in sub-Saharan Africa causing malnutrition, anemia, and retardation of physical and cognitive development. However, the effect of these diseases on physical fitness remains to be determined.Methodology: We investigated the relationship between schistosomiasis, soil-transmitted helminthiasis and physical performance of children, controlling for potential confounding of Plasmodium spp. infections and environmental parameters (i.e., ambient air temperature and humidity). A cross-sectional survey was carried out among 156 school children aged 7-15 years from Cote d'Ivoire. Each child had two stool and two urine samples examined for helminth eggs by microscopy. Additionally, children underwent a clinical examination, were tested for Plasmodium spp. infection with a rapid diagnostic test, and performed a maximal multistage 20 m shuttle run test to assess their maximal oxygen uptake (VO2 max) as a proxy for physical fitness.Principal Findings: The prevalence of Schistosoma haematobium, Plasmodium spp., Schistosoma mansoni, hookworm and Ascaris lumbricoides infections was 85.3%, 71.2%, 53.8%, 13.5% and 1.3%, respectively. Children with single, dual, triple, quadruple and quintuple species infections showed VO2 max of 52.7, 53.1, 52.2, 52.6 and 55.6 ml kg(-1) min(-1), respectively. The VO2 max of children with no parasite infections was 53.5 ml kg(-1) min(-1). No statistically significant difference was detected between any groups. Multivariable analysis revealed that VO2 max was influenced by sex (reference: female, coef. = 4.02, p