Microvascular architecture of breast lesions - Evaluation with contrast-enhanced ultrasonographic micro flow imaging
Microvascular architecture of breast lesions - Evaluation with contrast-enhanced ultrasonographic micro flow imaging
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DOI：
10.7863/jum.2008.27.6.833
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发表时间：
2008-06-01
影响因子：
2.3
通讯作者：
Zhu, Cai-Xia
中科院分区：
文献类型：
--
作者：
Du, Jing;Li, Feng-Hua;Zhu, Cai-Xia
目标。本研究的目的是评价微血流成像(MFI)结合超声造影对乳腺良恶性病变的分类和微血管构筑模式的有效性。方法：研究方法。对61例乳腺病变患者行超声造影和MFI检查。应用MFI评价乳腺肿瘤的微血管形态和分布特征。应用受试者工作特征曲线分析评价MFI的诊断价值，并分析微血管构筑类型。结果。手术病理分析显示良性病变29个，恶性病变32个。MFI的受试者工作特征曲线下面积(A)值为0.94，反映乳腺病变血管的总体特征。其准确性、敏感性和特异性分别为90.2%(55/61)、93.8%(30/32)和86.24(25/29)。外周血管形态及分布特征的A值为0.91，显著高于内部血管形态及分布特征的A(Z)值(P=0.019)。61个病灶的微血管构筑可分为3种类型：树状型、根毛型和蟹爪型。良性病变以树状为主(17例，占58.6%)，恶性病变以蟹爪样为主(20例，占62.5%)，根毛状者多见。良性病变11例(37.9%)，恶性病变8例(25%)。微血管构筑在良、恶性病变间差异有统计学意义(P
Objective. The purpose of this study was to evaluate the effectiveness of micro flow imaging (MFI) of the microvascular architecture with contrast-enhanced ultrasonography for classification of breast lesions as benign or malignant and, the microvascular architectural patterns. Methods. Contrast-enhanced ultrasonography and MFI were performed in 61 women with breast lesions. The microvascular morphologic and distribution features of the breast tumors were evaluated with MFI. Receiver operating characteristic curve analysis was used to evaluate the diagnostic value of MFI, and the microvascular architectural patterns were analyzed. Results. Surgical pathologic analysis showed 29 benign and 32 malignant lesions. For MFI, the area under the receiver operating characteristic curve (A) value for the overall features of the blood vessels for classification of breast lesions was 0.94. The accuracy, sensitivity, and specificity were 90.2% (55/61), 93.8% (30/32), and 86.24 (25/29), respectively. The A, value for the morphologic and distribution features of peripheral blood vessels was 0.91 which was significantly higher than the A(z) value for the morphologic and distribution features of interior vessels (P=.019). The microvascular architecture of the 61 lesions was categorized into 3 patterns: treelike, root hair-like, and crab claw-like. Benign lesions mainly displayed the treelike pattern (17 [58.6%]); malignant lesions tended to display the crab claw-like pattern (20 [62.5%]); and the root hair-like pattern was shown in. both benign and malignant lesions (11 [37.9%] and 8 [25%], respectively). The microvascular architecture showed significant differences between benign and malignant lesions (P