Irf6-Related Gene Regulatory Network Involved in Palate and Lip Development
Irf6-Related Gene Regulatory Network Involved in Palate and Lip Development
复制标题
参与上颚和嘴唇发育的 Irf6 相关基因调控网络
DOI：
10.1097/scs.0000000000001526
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发表时间：
2015-07-01
影响因子：
0.9
通讯作者：
Shen, Steve Guofang
中科院分区：
文献类型：
--
作者：
Dai, Jiewen;Yu, Hongbo;Shen, Steve Guofang
AbstractNumerous genes including Irf6 have been revealed to contribute to cleft lip with or without cleft palate (CL/P). In this study, we performed a systematic bioinformatics analysis of Irf6-related gene regulatory network involved in palate and lip development by using GeneDecks, DAVID, STRING, and GeneMANIA database. Our results showed that many CL/P candidate genes have relation with Irf6, and 9 of these genes, including Msx1, Pvrl1, Pax9, Jag2, Irf6, Tgfb3, Rara, Gli2, and Tgfb2, were enriched into the CL/P gene group. Some of these 9 genes also were commonly involved in different signaling pathways and different biological processes, and they also have protein-protein interactions with Irf6. These findings make us analyze the intricate function of Irf6 in a CL/P gene regulatory network, followed by guiding us to perform further functional studies on these genes in the future. This method also offers us a simple, cheap, but useful method to analyze the relationship with a gene regulatory network of a certain disease such as CL/P.
