INFLUENCE OF AGE AND PARITY ON THE DEVELOPMENT OF THE HUMAN BREAST
INFLUENCE OF AGE AND PARITY ON THE DEVELOPMENT OF THE HUMAN BREAST
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DOI：
10.1007/bf01833517
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发表时间：
1992-01-01
影响因子：
3.8
通讯作者：
RUSSO, IH
中科院分区：
文献类型：
--
作者：
RUSSO, J;RIVERA, R;RUSSO, IH
乳腺癌很大程度上受个体生育史的影响。怀孕具有保护作用，这是由于乳房分化程度的差异。这项工作的目的是确定人类乳房中存在的实质结构的数量和类型是否与女性的年龄和产次史有关。 51 个人类乳房样本是从 40 名年龄从 18 岁到 57 岁的经产妇女和 11 名年龄从 14 岁到 54 岁的未生育妇女进行双侧或单侧乳房缩小成形术中获得的。平均处理 100 克组织/样本以进行整体安装。总共检查了 650 张载玻片，并在光学显微镜下对 31,222 个结构进行了分类和计数。确定了以下乳腺结构：末端结构 (TS) 和小叶 (LOB) 1、2 和 3 型。绘制了总患者群体的结果，并分别绘制了未产妇和已产妇与年龄的结果。在14-18岁之间，总患者群体中Lob1、2和3的比例相似，在23岁至40岁之间，Lob1的百分比减少，Lob3的百分比增加，此时Lob3减少，Lob1增加到70%。 Lob2 和 TS 在分析的整个生命周期中没有表现出显着变化。单独分析发现，未生育女性的乳房主要由 Lob1 组成，Lob2 较少，Lob3 几乎完全不存在，而经产女性则具有较高频率的 Lob3，直到 40 岁为止，Lob3 都是主要结构。此后，它们的数量减少，Lob1 随之增加。这些变化导致生育过和未生育过的女性在 50 岁后的乳房结构出现相似的外观。结论是，未产妇和已产妇女的乳房发育模式存在显着差异。
Breast cancer is heavily influenced by the reproductive history of the individual. Pregnancy has a protective effect which is attributed to differences in the degree of differentiation of the breast. The purpose of this work was to determine whether the quantity and the type of parenchymal structures present in the human breast were related to the age and parity history of a woman. Fifty-one human breast samples were obtained from bilateral or unilateral reduction mammoplasties performed in 40 parous women ranging in age from 18 to 57 years, and 11 nulliparous women ranging in age from 14 to 54 years. An average of 100 grams of tissue/specimen were processed for whole mount. A total of 650 slides were examined and 31,222 structures were classified and counted under the light microscope. The following mammary structures were identified: terminal structures (TS), and lobules (LOB) type 1, 2, and 3. Results were plotted for the total patient population and separately for nulliparous and parous women against age. The total patient population contained similar proportions of Lob1, 2, and 3 between ages 14-18, with a reduction of percentage of Lob1 and increase in Lob3 between ages 23 to the middle forties, when Lob3 decreased and Lob1 increased to 70%. Lob2 and TS did not exhibit significant changes throughout the period of life analyzed. When analyzed separately it was found that the breasts of nulliparous women were predominantly composed of Lob1, fewer Lob2, with Lob3 almost completely absent, whereas parous women had a high frequency of Lob3, which were the predominant structures until the fourth decade of life. Thereafter, their number decreased, with a concomitant increase in Lob1. These changes resulted in a similar appearance in the architecture of the breast of parous and nulliparous women after the fifth decade of life. It was concluded that there are striking differences in the developmental pattern of the breast between nulliparous and parous women.