Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform
Estrogen Receptor α (ERα) and Estrogen Related Receptor α (ERRα) are both transcriptional regulators of the Runx2-I isoform
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DOI：
10.1016/j.mce.2013.01.024
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发表时间：
2013-04-30
影响因子：
4.1
通讯作者：
Fournier, Brigitte
中科院分区：
文献类型：
--
作者：
Kammerer, Martial;Gutzwiller, Sabine;Fournier, Brigitte
Runx 2是骨发育的主要调节因子，也被描述为致癌基因。雌激素受体α（ER α）和雌激素相关受体α（ERR α），都涉及骨代谢和乳腺癌，已被证明有共同的转录靶点。在这里，我们表明ER alpha是Runx 2-I转录的正调节因子。此外，在过氧化物酶体增殖物激活受体γ共激活因子-1 α（PGC-1 α）存在下，ERR α可作为Runx 2-I的转录激活因子。相反，ERR α在PGC-1 β存在下表现为Runx 2-I转录的负调节因子。ER α和ERR α通过Runx 2-I启动子上的共同雌激素受体反应元件相互作用。此外，雌激素调节PGC-1 β，进而能够调节ER α和ERR α转录活性。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Runx2 is a master regulator of bone development and has also been described as an oncogene. Estrogen Receptor alpha (ER alpha) and Estrogen Related Receptor alpha (ERR alpha), both implicated in bone metabolism and breast cancer, have been shown to share common transcriptional targets. Here, we show that ER alpha is a positive regulator of Runx2-I transcription. Moreover, ERR alpha can act as a transcriptional activator of Runx2-I in presence of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1 alpha). In contrast, ERR alpha behaves as a negative regulator of Runx2-I transcription in presence of PGC-1 beta. ER alpha and ERR alpha cross-talk via a common estrogen receptor response element on the Runx2-I promoter. In addition, estrogen regulates PGC-1 beta that in turn is able to modulate both ER alpha and ERR alpha transcriptional activity. (C) 2013 Elsevier Ireland Ltd. All rights reserved.